San Francisco 49ers 2025 schedule and complete game calendar
The 2025 NFL season is here. Take a look or download the complete calendar for San Francisco 49ers game schedule in 2025
Showing 16 of 16 games
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San Francisco 49ers | Date & Time↑Sorted ascending | Opponent | LocationNot sorted | VenueNot sorted | Score | Shop Teams | |
|---|---|---|---|---|---|---|---|
 | Sep 7, 2025 Sunday 4:05 PM EDT | San Francisco 49ers | Away | Lumen Field, Seattle | - : - | ||
 | Sep 14, 2025 Sunday 1:00 PM EDT | San Francisco 49ers | Away | Caesars Superdome, New Orleans | - : - | ||
San Francisco 49ers | Sep 21, 2025 Sunday 4:25 PM EDT |  | Home | Levi's® Stadium, Santa Clara | - : - | ||
San Francisco 49ers | Sep 28, 2025 Sunday 4:05 PM EDT |  | Home | Levi's® Stadium, Santa Clara | - : - | ||
 | Oct 2, 2025 Thursday 8:15 PM EDT | San Francisco 49ers | Away | SoFi Stadium, Inglewood | - : - | ||
 | Oct 12, 2025 Sunday 1:00 PM EDT | San Francisco 49ers | Away | Raymond James Stadium, Tampa | - : - | ||
San Francisco 49ers | Oct 19, 2025 Sunday 8:20 PM EDT |  | Home | Levi's® Stadium, Santa Clara | - : - | ||
 | Oct 26, 2025 Sunday 1:00 PM EDT | San Francisco 49ers | Away | NRG Stadium, Houston | - : - | ||
 | Nov 2, 2025 Sunday 1:00 PM EST | San Francisco 49ers | Away | MetLife Stadium, East Rutherford | - : - | ||
San Francisco 49ers | Nov 9, 2025 Sunday 4:25 PM EST | | Home | Levi's® Stadium, Santa Clara | - : - | ||
| Nov 16, 2025 Sunday 4:05 PM EST | San Francisco 49ers | Away | State Farm Stadium, Glendale | - : - | ||
San Francisco 49ers | Nov 24, 2025 Monday 8:15 PM EST |  | Home | Levi's® Stadium, Santa Clara | - : - | ||
 | Nov 30, 2025 Sunday 1:00 PM EST | San Francisco 49ers | Away | Huntington Bank Field, Cleveland | - : - | ||
San Francisco 49ers | Dec 14, 2025 Sunday 4:25 PM EST |  | Home | Levi's® Stadium, Santa Clara | - : - | ||
 | Dec 22, 2025 Monday 8:15 PM EST | San Francisco 49ers | Away | Lucas Oil Stadium, Indianapolis | - : - | ||
San Francisco 49ers | Dec 28, 2025 Sunday 8:20 PM EST |  | Home | Levi's® Stadium, Santa Clara | - : - |
VENUE
Lumen Field, Seattle
VENUE
Caesars Superdome, New Orleans
VENUE
Levi's® Stadium, Santa Clara
VENUE
Levi's® Stadium, Santa Clara
VENUE
SoFi Stadium, Inglewood
VENUE
Raymond James Stadium, Tampa
VENUE
Levi's® Stadium, Santa Clara
VENUE
MetLife Stadium, East Rutherford
VENUE
Levi's® Stadium, Santa Clara
VENUE
State Farm Stadium, Glendale
VENUE
Levi's® Stadium, Santa Clara
VENUE
Huntington Bank Field, Cleveland
VENUE
Levi's® Stadium, Santa Clara
VENUE
Lucas Oil Stadium, Indianapolis
VENUE
Levi's® Stadium, Santa Clara
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