Skip to content
MLB Head-to-Head
Houston Astros

Houston Astros

VS

21 - 29
San Diego Padres

San Diego Padres

Houston Astros vs San Diego Padres

Head-to-Head History (2010–2026)

50

Total Games

21

Astros Wins

29

Padres Wins

0

Draws

Rep Your Side

As an Amazon Associate we earn from qualifying purchases. Prices checked Sep 10, 2026.

New Era MLB Houston Astros Team Classic Home 39Thirty Stretch Fit Cap, Blue, Large/X-Large
New Era Only 2 left in stock - order soon.

New Era MLB Houston Astros Team Classic Home 39Thirty Stretch Fit Cap, Blue, Large/X-Large

$25.00 $28.83 −13% View on Amazon
47 MLB Team Color Primary Logo MVP Adjustable Hat, Adult One Size Fits All - San Diego Padres - Brown
47 In Stock

47 MLB Team Color Primary Logo MVP Adjustable Hat, Adult One Size Fits All - San Diego Padres - Brown

$36.99 View on Amazon

All Matchups (50)

Sun, Aug 9, 2026
MLB Regular Season
Houston Astros @ San Diego Padres
2 - 7
Petco Park, San Diego, CA | NBC/Peacock
Sat, Aug 8, 2026
MLB Regular Season
Houston Astros @ San Diego Padres
2 - 3
Petco Park, San Diego, CA | Space City Home Network
Fri, Aug 7, 2026
MLB Regular Season
Houston Astros @ San Diego Padres
6 - 3
Petco Park, San Diego, CA | Space City Home Network
Sun, Apr 20, 2025
MLB Regular Season
San Diego Padres @ Houston Astros
3 - 2
Daikin Park, Houston, TX | ESPN/ESPN App
Sat, Apr 19, 2025
MLB Regular Season
San Diego Padres @ Houston Astros
2 - 3
Daikin Park, Houston, TX | FS1, Space City Home Network
Fri, Apr 18, 2025
MLB Regular Season
San Diego Padres @ Houston Astros
4 - 6
Daikin Park, Houston, TX | Space City Home Network
Wed, Sep 18, 2024
MLB Regular Season
Houston Astros @ San Diego Padres
0 - 4
Petco Park, San Diego, CA | Space City Home Network
Tue, Sep 17, 2024
MLB Regular Season
Houston Astros @ San Diego Padres
4 - 3
Petco Park, San Diego, CA | TruTV, Space City Home Network
Mon, Sep 16, 2024
MLB Regular Season
Houston Astros @ San Diego Padres
1 - 3
Petco Park, San Diego, CA | Space City Home Network
Sun, Sep 10, 2023
MLB Regular Season
San Diego Padres @ Houston Astros
2 - 12
Minute Maid Park, Houston, TX | MLBN (out-of-market only), Space City Home Network
Sat, Sep 9, 2023
MLB Regular Season
San Diego Padres @ Houston Astros
5 - 7
Minute Maid Park, Houston, TX | MLBN (out-of-market only), Space City Home Network
Fri, Sep 8, 2023
MLB Regular Season
San Diego Padres @ Houston Astros
11 - 2
Minute Maid Park, Houston, TX | Apple TV
Sun, Sep 5, 2021
MLB Regular Season
Houston Astros @ San Diego Padres
3 - 4
Petco Park, San Diego, CA | MLBN (out-of-market only), Space City Home Network
Sat, Sep 4, 2021
MLB Regular Season
Houston Astros @ San Diego Padres
2 - 10
Petco Park, San Diego, CA | Space City Home Network
Fri, Sep 3, 2021
MLB Regular Season
Houston Astros @ San Diego Padres
6 - 3
Petco Park, San Diego, CA | Space City Home Network
Sun, May 30, 2021
MLB Regular Season
San Diego Padres @ Houston Astros
4 - 7
Minute Maid Park, Houston, TX | Space City Home Network
Sat, May 29, 2021
MLB Regular Season
San Diego Padres @ Houston Astros
11 - 8
Minute Maid Park, Houston, TX | MLBN (out-of-market only), Space City Home Network
Fri, May 28, 2021
MLB Regular Season
San Diego Padres @ Houston Astros
10 - 3
Minute Maid Park, Houston, TX | MLBN (out-of-market only), Space City Home Network
Sun, Aug 23, 2020
MLB Regular Season
Houston Astros @ San Diego Padres
3 - 5
Petco Park, San Diego, CA | ESPN/ESPN App, Space City Home Network
Sat, Aug 22, 2020
MLB Regular Season
Houston Astros @ San Diego Padres
2 - 13
Petco Park, San Diego, CA | MLBN (out-of-market only), ATT SportsNet-SW+
Fri, Aug 21, 2020
MLB Regular Season
Houston Astros @ San Diego Padres
3 - 4
Petco Park, San Diego, CA | Space City Home Network
Sun, Apr 8, 2018
MLB Regular Season
San Diego Padres @ Houston Astros
1 - 4
Minute Maid Park, Houston, TX | Space City Home Network
Sat, Apr 7, 2018
MLB Regular Season
San Diego Padres @ Houston Astros
0 - 1
Minute Maid Park, Houston, TX | MLBN (out-of-market only), Space City Home Network
Fri, Apr 6, 2018
MLB Regular Season
San Diego Padres @ Houston Astros
4 - 1
Minute Maid Park, Houston, TX | Space City Home Network
Wed, Apr 29, 2015
MLB Regular Season
Houston Astros @ San Diego Padres
7 - 2
Petco Park, San Diego, CA | ROOT SPORTS
Tue, Apr 28, 2015
MLB Regular Season
Houston Astros @ San Diego Padres
14 - 3
Petco Park, San Diego, CA | MLBN, ROOT SPORTS
Mon, Apr 27, 2015
MLB Regular Season
Houston Astros @ San Diego Padres
9 - 4
Petco Park, San Diego, CA | MLBN, ROOT SPORTS
Thu, Jul 19, 2012
MLB Regular Season
Houston Astros @ San Diego Padres
0 - 1
Petco Park, San Diego, CA | FS-H
Wed, Jul 18, 2012
MLB Regular Season
Houston Astros @ San Diego Padres
4 - 8
Petco Park, San Diego, CA | FS-H
Tue, Jul 17, 2012
MLB Regular Season
Houston Astros @ San Diego Padres
2 - 8
Petco Park, San Diego, CA | FS-H
Mon, Jul 16, 2012
MLB Regular Season
Houston Astros @ San Diego Padres
2 - 0
Petco Park, San Diego, CA | FS-H
Thu, Jun 28, 2012
MLB Regular Season
San Diego Padres @ Houston Astros
7 - 3
Minute Maid Park, Houston, TX | FS-H
Wed, Jun 27, 2012
MLB Regular Season
San Diego Padres @ Houston Astros
0 - 1
Minute Maid Park, Houston, TX | FS-H
Tue, Jun 26, 2012
MLB Regular Season
San Diego Padres @ Houston Astros
3 - 5
Minute Maid Park, Houston, TX | FS-H
Mon, Jun 25, 2012
MLB Regular Season
San Diego Padres @ Houston Astros
8 - 7
Minute Maid Park, Houston, TX | FS-H
Sun, Jun 5, 2011
MLB Regular Season
Houston Astros @ San Diego Padres
2 - 7
PETCO Park, San Diego, CA
Sat, Jun 4, 2011
MLB Regular Season
Houston Astros @ San Diego Padres
3 - 6
PETCO Park, San Diego, CA | MLBN, FS-H HD
Fri, Jun 3, 2011
MLB Regular Season
Houston Astros @ San Diego Padres
1 - 3
PETCO Park, San Diego, CA | FS-H HD, Dish450
Thu, Jun 2, 2011
MLB Regular Season
Houston Astros @ San Diego Padres
7 - 4
PETCO Park, San Diego, CA | FS-H HD
Sun, Apr 17, 2011
MLB Regular Season
San Diego Padres @ Houston Astros
8 - 6
Minute Maid Park, Houston, TX
Sat, Apr 16, 2011
MLB Regular Season
San Diego Padres @ Houston Astros
3 - 5
Minute Maid Park, Houston, TX | DishHD-9514
Fri, Apr 15, 2011
MLB Regular Season
San Diego Padres @ Houston Astros
4 - 2
Minute Maid Park, Houston, TX | DishHD-9516
Thu, Apr 14, 2011
MLB Regular Season
San Diego Padres @ Houston Astros
0 - 1
Minute Maid Park, Houston, TX | DishHD-9516
Sun, Jul 4, 2010
MLB Regular Season
Houston Astros @ San Diego Padres
2 - 3
PETCO Park, San Diego, CA | FS-H
Sat, Jul 3, 2010
MLB Regular Season
Houston Astros @ San Diego Padres
0 - 1
PETCO Park, San Diego, CA | FS-H HD
Fri, Jul 2, 2010
MLB Regular Season
Houston Astros @ San Diego Padres
0 - 3
PETCO Park, San Diego, CA | FS-H
Thu, Jul 1, 2010
MLB Regular Season
Houston Astros @ San Diego Padres
6 - 3
PETCO Park, San Diego, CA | FS-H
Sun, May 9, 2010
MLB Regular Season
San Diego Padres @ Houston Astros
3 - 4
Minute Maid Park, Houston, TX | FS-H HD
Sat, May 8, 2010
MLB Regular Season
San Diego Padres @ Houston Astros
2 - 1
Minute Maid Park, Houston, TX | FS-H HD
Fri, May 7, 2010
MLB Regular Season
San Diego Padres @ Houston Astros
7 - 0
Minute Maid Park, Houston, TX | FS-H HD

The Houston Astros and San Diego Padres have faced each other 50 times in the MLB. The all-time series record is 21-29. View the complete head-to-head matchup history between these two MLB teams.

Series records

Decided meetings only, 2010–2026. Every number is from the games listed above.

Longest Houston Astros run
3 straight · Apr 27 – Apr 29, 2015
Longest San Diego Padres run
5 straight · Aug 21, 2020 – May 29, 2021
Biggest Houston Astros win
14-3 · Apr 28, 2015
Biggest San Diego Padres win
13-2 · Aug 22, 2020
Houston Astros Schedule San Diego Padres Schedule All MLB Teams
Today's Games