NFL Head-to-Head
Arizona Cardinals vs San Francisco 49ers
Head-to-Head History (2010–2026)
33
Total Games
15
Cardinals Wins
18
49ers Wins
0
Draws
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All Matchups (33)
Sun, Sep 27, 2026
Week 3
Regular Season Arizona Cardinals
@
San Francisco 49ers
30 - 36
Levi's® Stadium, Santa Clara | FOX
Sun, Nov 16, 2025
Week 11
Regular Season San Francisco 49ers
@
Arizona Cardinals
41 - 22
State Farm Stadium, Glendale | FOX
Sun, Sep 21, 2025
Week 3
Regular Season Arizona Cardinals
@
San Francisco 49ers
15 - 16
Levi's® Stadium, Santa Clara | FOX
Sun, Jan 5, 2025
Week 18
Regular Season San Francisco 49ers
@
Arizona Cardinals
24 - 47
State Farm Stadium, Glendale | FOX
Sun, Oct 6, 2024
Week 5
Regular Season Arizona Cardinals
@
San Francisco 49ers
24 - 23
Levi's® Stadium, Santa Clara | FOX
Sun, Dec 17, 2023
Week 15
Regular Season San Francisco 49ers
@
Arizona Cardinals
45 - 29
State Farm Stadium, Glendale | CBS
Sun, Oct 1, 2023
Week 4
Regular Season Arizona Cardinals
@
San Francisco 49ers
16 - 35
Levi's® Stadium, Santa Clara | FOX
Sun, Jan 8, 2023
Week 18
Regular Season Arizona Cardinals
@
San Francisco 49ers
13 - 38
Levi's® Stadium, Santa Clara | FOX
Mon, Nov 21, 2022
Week 11
Regular Season San Francisco 49ers
@
Arizona Cardinals
38 - 10
Estadio Banorte, Mexico City | ESPN, ESPN Deportes
Sun, Nov 7, 2021
Week 9
Regular Season Arizona Cardinals
@
San Francisco 49ers
31 - 17
Levi's® Stadium, Santa Clara | FOX
Sun, Oct 10, 2021
Week 5
Regular Season San Francisco 49ers
@
Arizona Cardinals
10 - 17
State Farm Stadium, Glendale | FOX
Sat, Dec 26, 2020
Week 16
Regular Season San Francisco 49ers
@
Arizona Cardinals
20 - 12
State Farm Stadium, Glendale | AMAZON
Sun, Sep 13, 2020
Week 1
Regular Season Arizona Cardinals
@
San Francisco 49ers
24 - 20
Levi's® Stadium, Santa Clara | FOX
Sun, Nov 17, 2019
Week 11
Regular Season Arizona Cardinals
@
San Francisco 49ers
26 - 36
Levi's® Stadium, Santa Clara | FOX
Thu, Oct 31, 2019
Week 9
Regular Season San Francisco 49ers
@
Arizona Cardinals
28 - 25
State Farm Stadium, Glendale | FOX, NFL NETWORK, AMAZON
Sun, Oct 28, 2018
Week 8
Regular Season San Francisco 49ers
@
Arizona Cardinals
15 - 18
State Farm Stadium, Glendale | FOX
Sun, Oct 7, 2018
Week 5
Regular Season Arizona Cardinals
@
San Francisco 49ers
28 - 18
Levi's® Stadium, Santa Clara | FOX
Sun, Nov 5, 2017
Week 9
Regular Season Arizona Cardinals
@
San Francisco 49ers
20 - 10
Levi's® Stadium, Santa Clara | FOX
Sun, Oct 1, 2017
Week 4
Regular Season San Francisco 49ers
@
Arizona Cardinals
15 - 18
State Farm Stadium, Glendale | FOX
Sun, Nov 13, 2016
Week 10
Regular Season San Francisco 49ers
@
Arizona Cardinals
20 - 23
State Farm Stadium, Glendale | FOX
Thu, Oct 6, 2016
Week 5
Regular Season Arizona Cardinals
@
San Francisco 49ers
33 - 21
Levi's® Stadium, Santa Clara | CBS, NFL NETWORK
Sun, Nov 29, 2015
Week 12
Regular Season Arizona Cardinals
@
San Francisco 49ers
19 - 13
Levi's® Stadium, Santa Clara | FOX
Sun, Sep 27, 2015
Week 3
Regular Season San Francisco 49ers
@
Arizona Cardinals
7 - 47
State Farm Stadium, Glendale | FOX
Sun, Dec 28, 2014
Week 17
Regular Season Arizona Cardinals
@
San Francisco 49ers
17 - 20
Levi's® Stadium, Santa Clara | FOX
Sun, Sep 21, 2014
Week 3
Regular Season San Francisco 49ers
@
Arizona Cardinals
14 - 23
State Farm Stadium, Glendale | FOX
Sun, Dec 29, 2013
Week 17
Regular Season San Francisco 49ers
@
Arizona Cardinals
23 - 20
State Farm Stadium, Glendale | FOX
Sun, Oct 13, 2013
Week 6
Regular Season Arizona Cardinals
@
San Francisco 49ers
20 - 32
Candlestick Park, San Francisco | FOX
Sun, Dec 30, 2012
Week 17
Regular Season Arizona Cardinals
@
San Francisco 49ers
13 - 27
Candlestick Park, San Francisco
Mon, Oct 29, 2012
Week 8
Regular Season San Francisco 49ers
@
Arizona Cardinals
24 - 3
State Farm Stadium, Glendale
Sun, Dec 11, 2011
Week 14
Regular Season San Francisco 49ers
@
Arizona Cardinals
19 - 21
State Farm Stadium, Glendale
Sun, Nov 20, 2011
Week 11
Regular Season Arizona Cardinals
@
San Francisco 49ers
7 - 23
Candlestick Park, San Francisco
Sun, Jan 2, 2011
Week 17
Regular Season Arizona Cardinals
@
San Francisco 49ers
7 - 38
Candlestick Park, San Francisco
Mon, Nov 29, 2010
Week 12
Regular Season San Francisco 49ers
@
Arizona Cardinals
27 - 6
State Farm Stadium, Glendale
The Arizona Cardinals and San Francisco 49ers have faced each other 33 times in the NFL. The all-time series record is 15-18. View the complete head-to-head matchup history between these two NFL teams.
Series records
Decided meetings only, 2010–2026. Every number is from the games listed above.
- Longest Arizona Cardinals run
- 8 straight · Sep 27, 2015 – Oct 28, 2018
- Longest San Francisco 49ers run
- 4 straight · Oct 29, 2012 – Dec 29, 2013
- Biggest Arizona Cardinals win
- 47-7 · Sep 27, 2015
- Biggest San Francisco 49ers win
- 38-7 · Jan 2, 2011
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