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NFL Head-to-Head
Arizona Cardinals

Arizona Cardinals

VS

15 - 17
San Francisco 49ers

San Francisco 49ers

Arizona Cardinals vs San Francisco 49ers

Head-to-Head History (2010–2026)

32

Total Games

15

Cardinals Wins

17

49ers Wins

0

Draws

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All Matchups (33)

Sun, Sep 27, 2026 Week 3
Regular Season
Arizona Cardinals @ San Francisco 49ers
Scheduled
Levi's® Stadium, Santa Clara | FOX
Sun, Nov 16, 2025 Week 11
Regular Season
San Francisco 49ers @ Arizona Cardinals
41 - 22
State Farm Stadium, Glendale | FOX
Sun, Sep 21, 2025 Week 3
Regular Season
Arizona Cardinals @ San Francisco 49ers
15 - 16
Levi's® Stadium, Santa Clara | FOX
Sun, Jan 5, 2025 Week 18
Regular Season
San Francisco 49ers @ Arizona Cardinals
24 - 47
State Farm Stadium, Glendale | FOX
Sun, Oct 6, 2024 Week 5
Regular Season
Arizona Cardinals @ San Francisco 49ers
24 - 23
Levi's® Stadium, Santa Clara | FOX
Sun, Dec 17, 2023 Week 15
Regular Season
San Francisco 49ers @ Arizona Cardinals
45 - 29
State Farm Stadium, Glendale | CBS
Sun, Oct 1, 2023 Week 4
Regular Season
Arizona Cardinals @ San Francisco 49ers
16 - 35
Levi's® Stadium, Santa Clara | FOX
Sun, Jan 8, 2023 Week 18
Regular Season
Arizona Cardinals @ San Francisco 49ers
13 - 38
Levi's® Stadium, Santa Clara | FOX
Mon, Nov 21, 2022 Week 11
Regular Season
San Francisco 49ers @ Arizona Cardinals
38 - 10
Estadio Banorte, Mexico City | ESPN, ESPN Deportes
Sun, Nov 7, 2021 Week 9
Regular Season
Arizona Cardinals @ San Francisco 49ers
31 - 17
Levi's® Stadium, Santa Clara | FOX
Sun, Oct 10, 2021 Week 5
Regular Season
San Francisco 49ers @ Arizona Cardinals
10 - 17
State Farm Stadium, Glendale | FOX
Sat, Dec 26, 2020 Week 16
Regular Season
San Francisco 49ers @ Arizona Cardinals
20 - 12
State Farm Stadium, Glendale | AMAZON
Sun, Sep 13, 2020 Week 1
Regular Season
Arizona Cardinals @ San Francisco 49ers
24 - 20
Levi's® Stadium, Santa Clara | FOX
Sun, Nov 17, 2019 Week 11
Regular Season
Arizona Cardinals @ San Francisco 49ers
26 - 36
Levi's® Stadium, Santa Clara | FOX
Thu, Oct 31, 2019 Week 9
Regular Season
San Francisco 49ers @ Arizona Cardinals
28 - 25
State Farm Stadium, Glendale | FOX, NFL NETWORK, AMAZON
Sun, Oct 28, 2018 Week 8
Regular Season
San Francisco 49ers @ Arizona Cardinals
15 - 18
State Farm Stadium, Glendale | FOX
Sun, Oct 7, 2018 Week 5
Regular Season
Arizona Cardinals @ San Francisco 49ers
28 - 18
Levi's® Stadium, Santa Clara | FOX
Sun, Nov 5, 2017 Week 9
Regular Season
Arizona Cardinals @ San Francisco 49ers
20 - 10
Levi's® Stadium, Santa Clara | FOX
Sun, Oct 1, 2017 Week 4
Regular Season
San Francisco 49ers @ Arizona Cardinals
15 - 18
State Farm Stadium, Glendale | FOX
Sun, Nov 13, 2016 Week 10
Regular Season
San Francisco 49ers @ Arizona Cardinals
20 - 23
State Farm Stadium, Glendale | FOX
Thu, Oct 6, 2016 Week 5
Regular Season
Arizona Cardinals @ San Francisco 49ers
33 - 21
Levi's® Stadium, Santa Clara | CBS, NFL NETWORK
Sun, Nov 29, 2015 Week 12
Regular Season
Arizona Cardinals @ San Francisco 49ers
19 - 13
Levi's® Stadium, Santa Clara | FOX
Sun, Sep 27, 2015 Week 3
Regular Season
San Francisco 49ers @ Arizona Cardinals
7 - 47
State Farm Stadium, Glendale | FOX
Sun, Dec 28, 2014 Week 17
Regular Season
Arizona Cardinals @ San Francisco 49ers
17 - 20
Levi's® Stadium, Santa Clara | FOX
Sun, Sep 21, 2014 Week 3
Regular Season
San Francisco 49ers @ Arizona Cardinals
14 - 23
State Farm Stadium, Glendale | FOX
Sun, Dec 29, 2013 Week 17
Regular Season
San Francisco 49ers @ Arizona Cardinals
23 - 20
State Farm Stadium, Glendale | FOX
Sun, Oct 13, 2013 Week 6
Regular Season
Arizona Cardinals @ San Francisco 49ers
20 - 32
Candlestick Park, San Francisco | FOX
Sun, Dec 30, 2012 Week 17
Regular Season
Arizona Cardinals @ San Francisco 49ers
13 - 27
Candlestick Park, San Francisco
Mon, Oct 29, 2012 Week 8
Regular Season
San Francisco 49ers @ Arizona Cardinals
24 - 3
State Farm Stadium, Glendale
Sun, Dec 11, 2011 Week 14
Regular Season
San Francisco 49ers @ Arizona Cardinals
19 - 21
State Farm Stadium, Glendale
Sun, Nov 20, 2011 Week 11
Regular Season
Arizona Cardinals @ San Francisco 49ers
7 - 23
Candlestick Park, San Francisco
Sun, Jan 2, 2011 Week 17
Regular Season
Arizona Cardinals @ San Francisco 49ers
7 - 38
Candlestick Park, San Francisco
Mon, Nov 29, 2010 Week 12
Regular Season
San Francisco 49ers @ Arizona Cardinals
27 - 6
State Farm Stadium, Glendale

The Arizona Cardinals and San Francisco 49ers have faced each other 33 times in the NFL. The all-time series record is 15-17. View the complete head-to-head matchup history between these two NFL teams.

Series records

Decided meetings only, 2010–2025. Every number is from the games listed above.

Longest Arizona Cardinals run
8 straight · Sep 27, 2015 – Oct 28, 2018
Longest San Francisco 49ers run
4 straight · Oct 29, 2012 – Dec 29, 2013
Biggest Arizona Cardinals win
47-7 · Sep 27, 2015
Biggest San Francisco 49ers win
38-7 · Jan 2, 2011
Arizona Cardinals Schedule San Francisco 49ers Schedule All NFL Teams
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