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NFL Head-to-Head
Los Angeles Rams

Los Angeles Rams

VS

12 - 1 - 21
San Francisco 49ers

San Francisco 49ers

Los Angeles Rams vs San Francisco 49ers

Head-to-Head History (2010–2026)

34

Total Games

12

Rams Wins

21

49ers Wins

1

Draws

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All Matchups (35)

Sun, Dec 13, 2026 Week 14
Regular Season
Los Angeles Rams @ San Francisco 49ers
Scheduled
Levi's® Stadium, Santa Clara | FOX
Thu, Sep 10, 2026 Week 1
Regular Season
San Francisco 49ers @ Los Angeles Rams
27 - 7
Melbourne Cricket Ground, East Melbourne | NETFLIX
Sun, Nov 9, 2025 Week 10
Regular Season
Los Angeles Rams @ San Francisco 49ers
42 - 26
Levi's® Stadium, Santa Clara | FOX
Thu, Oct 2, 2025 Week 5
Regular Season
San Francisco 49ers @ Los Angeles Rams
26 - 23
SoFi Stadium, Inglewood | Prime Video, PRIME, PRIMESPANISH, PRIMEALT1
Thu, Dec 12, 2024 Week 15
Regular Season
Los Angeles Rams @ San Francisco 49ers
12 - 6
Levi's® Stadium, Santa Clara | Prime Video, PRIME, PRIMESPANISH, PRIMEALT1
Sun, Sep 22, 2024 Week 3
Regular Season
San Francisco 49ers @ Los Angeles Rams
24 - 27
SoFi Stadium, Inglewood | FOX
Sun, Jan 7, 2024 Week 18
Regular Season
Los Angeles Rams @ San Francisco 49ers
21 - 20
Levi's® Stadium, Santa Clara | FOX
Sun, Sep 17, 2023 Week 2
Regular Season
San Francisco 49ers @ Los Angeles Rams
30 - 23
SoFi Stadium, Inglewood | FOX
Sun, Oct 30, 2022 Week 8
Regular Season
San Francisco 49ers @ Los Angeles Rams
31 - 14
SoFi Stadium, Inglewood | FOX
Mon, Oct 3, 2022 Week 4
Regular Season
Los Angeles Rams @ San Francisco 49ers
9 - 24
Levi's® Stadium, Santa Clara | ESPN, ESPN2, ESPN Deportes
Sun, Jan 30, 2022 Week 3
Postseason · Conference Championship
San Francisco 49ers @ Los Angeles Rams
17 - 20
SoFi Stadium, Inglewood | FOX
Sun, Jan 9, 2022 Week 18
Regular Season
San Francisco 49ers @ Los Angeles Rams
27 - 24
SoFi Stadium, Inglewood | FOX
Mon, Nov 15, 2021 Week 10
Regular Season
Los Angeles Rams @ San Francisco 49ers
10 - 31
Levi's® Stadium, Santa Clara | ESPN, ESPN2
Sun, Nov 29, 2020 Week 12
Regular Season
San Francisco 49ers @ Los Angeles Rams
23 - 20
SoFi Stadium, Inglewood | FOX
Sun, Oct 18, 2020 Week 6
Regular Season
Los Angeles Rams @ San Francisco 49ers
16 - 24
Levi's® Stadium, Santa Clara | NBC
Sat, Dec 21, 2019 Week 16
Regular Season
Los Angeles Rams @ San Francisco 49ers
31 - 34
Levi's® Stadium, Santa Clara | NFL NETWORK
Sun, Oct 13, 2019 Week 6
Regular Season
San Francisco 49ers @ Los Angeles Rams
20 - 7
Los Angeles Memorial Coliseum, Los Angeles | FOX
Sun, Dec 30, 2018 Week 17
Regular Season
San Francisco 49ers @ Los Angeles Rams
32 - 48
Los Angeles Memorial Coliseum, Los Angeles | FOX
Sun, Oct 21, 2018 Week 7
Regular Season
Los Angeles Rams @ San Francisco 49ers
39 - 10
Levi's® Stadium, Santa Clara | CBS
Sun, Dec 31, 2017 Week 17
Regular Season
San Francisco 49ers @ Los Angeles Rams
34 - 13
Los Angeles Memorial Coliseum, Los Angeles | FOX
Thu, Sep 21, 2017 Week 3
Regular Season
Los Angeles Rams @ San Francisco 49ers
41 - 39
Levi's® Stadium, Santa Clara | NFL NETWORK
Sat, Dec 24, 2016 Week 16
Regular Season
San Francisco 49ers @ Los Angeles Rams
22 - 21
Los Angeles Memorial Coliseum, Los Angeles | FOX
Mon, Sep 12, 2016 Week 1
Regular Season
Los Angeles Rams @ San Francisco 49ers
0 - 28
Levi's® Stadium, Santa Clara | ESPN
Sun, Jan 3, 2016 Week 17
Regular Season
Los Angeles Rams @ San Francisco 49ers
16 - 19
Levi's® Stadium, Santa Clara | CBS
Sun, Nov 1, 2015 Week 8
Regular Season
San Francisco 49ers @ Los Angeles Rams
6 - 27
Edward Jones Dome, St. Louis | FOX
Sun, Nov 2, 2014 Week 9
Regular Season
Los Angeles Rams @ San Francisco 49ers
13 - 10
Levi's® Stadium, Santa Clara | FOX
Mon, Oct 13, 2014 Week 6
Regular Season
San Francisco 49ers @ Los Angeles Rams
31 - 17
Edward Jones Dome, St. Louis | ESPN
Sun, Dec 1, 2013 Week 13
Regular Season
Los Angeles Rams @ San Francisco 49ers
13 - 23
Candlestick Park, San Francisco | FOX
Thu, Sep 26, 2013 Week 4
Regular Season
San Francisco 49ers @ Los Angeles Rams
35 - 11
Edward Jones Dome, St. Louis | NFL NETWORK
Sun, Dec 2, 2012 Week 13
Regular Season
San Francisco 49ers @ Los Angeles Rams
13 - 16
Edward Jones Dome, St. Louis
Sun, Nov 11, 2012 Week 10
Regular Season
Los Angeles Rams @ San Francisco 49ers
24 - 24
Candlestick Park, San Francisco
Sun, Jan 1, 2012 Week 17
Regular Season
San Francisco 49ers @ Los Angeles Rams
34 - 27
Edward Jones Dome, St. Louis
Sun, Dec 4, 2011 Week 13
Regular Season
Los Angeles Rams @ San Francisco 49ers
0 - 26
Candlestick Park, San Francisco
Sun, Dec 26, 2010 Week 16
Regular Season
San Francisco 49ers @ Los Angeles Rams
17 - 25
Edward Jones Dome, St. Louis
Sun, Nov 14, 2010 Week 10
Regular Season
Los Angeles Rams @ San Francisco 49ers
20 - 23
Candlestick Park, San Francisco

The Los Angeles Rams and San Francisco 49ers have faced each other 35 times in the NFL. The all-time series record is 12-21-1. View the complete head-to-head matchup history between these two NFL teams.

Series records

Decided meetings only, 2010–2026. Every number is from the games listed above.

Longest Los Angeles Rams run
3 straight · Jan 7 – Dec 12, 2024
Longest San Francisco 49ers run
6 straight · Oct 13, 2019 – Jan 9, 2022
Biggest Los Angeles Rams win
39-10 · Oct 21, 2018
Biggest San Francisco 49ers win
28-0 · Sep 12, 2016
Los Angeles Rams Schedule San Francisco 49ers Schedule All NFL Teams
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