| Thu, Feb 20, 2025 | Los Angeles Dodgers | Chicago Cubs vs Los Angeles Dodgers - Thu, Feb 20, 2025 | Away | Camelback Ranch |
| Fri, Feb 21, 2025 | Los Angeles Dodgers | Chicago Cubs vs Los Angeles Dodgers - Fri, Feb 21, 2025 | Home | Sloan Park |
| Sat, Feb 22, 2025 | Chicago White Sox | Chicago Cubs vs Chicago White Sox - Sat, Feb 22, 2025 | Home | Sloan Park |
| Sun, Feb 23, 2025 | Texas Rangers | Chicago Cubs vs Texas Rangers - Sun, Feb 23, 2025 | Home | Sloan Park |
| Mon, Feb 24, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Mon, Feb 24, 2025 | Away | Peoria Stadium |
| Tue, Feb 25, 2025 | Arizona Diamondbacks | Chicago Cubs vs Arizona Diamondbacks - Tue, Feb 25, 2025 | Home | Sloan Park |
| Wed, Feb 26, 2025 | San Francisco Giants | Chicago Cubs vs San Francisco Giants - Wed, Feb 26, 2025 | Away | Scottsdale Stadium |
| Thu, Feb 27, 2025 | Los Angeles Angels | Chicago Cubs vs Los Angeles Angels - Thu, Feb 27, 2025 | Home | Sloan Park |
| Fri, Feb 28, 2025 | Texas Rangers | Chicago Cubs vs Texas Rangers - Fri, Feb 28, 2025 | Away | Surprise Stadium |
| Sat, Mar 1, 2025 | Cleveland Guardians | Chicago Cubs vs Cleveland Guardians - Sat, Mar 1, 2025 | Home | Sloan Park |
| Sat, Mar 1, 2025 | Kansas City Royals | Chicago Cubs vs Kansas City Royals - Sat, Mar 1, 2025 | Away | Surprise Stadium |
| Sun, Mar 2, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Sun, Mar 2, 2025 | Home | Sloan Park |
| Mon, Mar 3, 2025 | Arizona Diamondbacks | Chicago Cubs vs Arizona Diamondbacks - Mon, Mar 3, 2025 | Away | Salt River Fields at Talking Stick |
| Tue, Mar 4, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Tue, Mar 4, 2025 | Home | Sloan Park |
| Thu, Mar 6, 2025 | Kansas City Royals | Chicago Cubs vs Kansas City Royals - Thu, Mar 6, 2025 | Home | Sloan Park |
| Fri, Mar 7, 2025 | Chicago White Sox | Chicago Cubs vs Chicago White Sox - Fri, Mar 7, 2025 | Away | Camelback Ranch |
| Sat, Mar 8, 2025 | Seattle Mariners | Chicago Cubs vs Seattle Mariners - Sat, Mar 8, 2025 | Home | Sloan Park |
| Sun, Mar 9, 2025 | San Francisco Giants | Chicago Cubs vs San Francisco Giants - Sun, Mar 9, 2025 | Home | Sloan Park |
| Mon, Mar 10, 2025 | Cleveland Guardians | Chicago Cubs vs Cleveland Guardians - Mon, Mar 10, 2025 | Away | Goodyear Ballpark |
| Tue, Mar 11, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Tue, Mar 11, 2025 | Home | Sloan Park |
| Sat, Mar 15, 2025 | Hanshin Tigers | Chicago Cubs vs Hanshin Tigers - Sat, Mar 15, 2025 | Away | Tokyo Dome |
| Sun, Mar 16, 2025 | Tokyo Yomiuri Giants | Chicago Cubs vs Tokyo Yomiuri Giants - Sun, Mar 16, 2025 | Away | Tokyo Dome |
| Tue, Mar 18, 2025 | Los Angeles Dodgers | Chicago Cubs vs Los Angeles Dodgers - Tue, Mar 18, 2025 | Home | Tokyo Dome |
| Wed, Mar 19, 2025 | Los Angeles Dodgers | Chicago Cubs vs Los Angeles Dodgers - Wed, Mar 19, 2025 | Home | Tokyo Dome |
| Fri, Mar 21, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Fri, Mar 21, 2025 | Home | Sloan Park |
| Sat, Mar 22, 2025 | Colorado Rockies | Chicago Cubs vs Colorado Rockies - Sat, Mar 22, 2025 | Home | Sloan Park |
| Sun, Mar 23, 2025 | Oakland Athletics | Chicago Cubs vs Oakland Athletics - Sun, Mar 23, 2025 | Home | Sloan Park |
| Mon, Mar 24, 2025 | Atlanta Braves | Chicago Cubs vs Atlanta Braves - Mon, Mar 24, 2025 | Home | Sloan Park |
| Tue, Mar 25, 2025 | Atlanta Braves | Chicago Cubs vs Atlanta Braves - Tue, Mar 25, 2025 | Home | Sloan Park |
| Thu, Mar 27, 2025 | Arizona Diamondbacks | Chicago Cubs vs Arizona Diamondbacks - Thu, Mar 27, 2025 | Away | Chase Field |
| Fri, Mar 28, 2025 | Arizona Diamondbacks | Chicago Cubs vs Arizona Diamondbacks - Fri, Mar 28, 2025 | Away | Chase Field |
| Sat, Mar 29, 2025 | Arizona Diamondbacks | Chicago Cubs vs Arizona Diamondbacks - Sat, Mar 29, 2025 | Away | Chase Field |
| Sun, Mar 30, 2025 | Arizona Diamondbacks | Chicago Cubs vs Arizona Diamondbacks - Sun, Mar 30, 2025 | Away | Chase Field |
| Mon, Mar 31, 2025 | Oakland Athletics | Chicago Cubs vs Oakland Athletics - Mon, Mar 31, 2025 | Away | Sutter Health Park |
| Tue, Apr 1, 2025 | Oakland Athletics | Chicago Cubs vs Oakland Athletics - Tue, Apr 1, 2025 | Away | Sutter Health Park |
| Wed, Apr 2, 2025 | Oakland Athletics | Chicago Cubs vs Oakland Athletics - Wed, Apr 2, 2025 | Away | Sutter Health Park |
| Fri, Apr 4, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Fri, Apr 4, 2025 | Home | Wrigley Field |
| Sat, Apr 5, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Sat, Apr 5, 2025 | Home | Wrigley Field |
| Sun, Apr 6, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Sun, Apr 6, 2025 | Home | Wrigley Field |
| Mon, Apr 7, 2025 | Texas Rangers | Chicago Cubs vs Texas Rangers - Mon, Apr 7, 2025 | Home | Wrigley Field |
| Tue, Apr 8, 2025 | Texas Rangers | Chicago Cubs vs Texas Rangers - Tue, Apr 8, 2025 | Home | Wrigley Field |
| Wed, Apr 9, 2025 | Texas Rangers | Chicago Cubs vs Texas Rangers - Wed, Apr 9, 2025 | Home | Wrigley Field |
| Fri, Apr 11, 2025 | Los Angeles Dodgers | Chicago Cubs vs Los Angeles Dodgers - Fri, Apr 11, 2025 | Away | Dodger Stadium |
| Sat, Apr 12, 2025 | Los Angeles Dodgers | Chicago Cubs vs Los Angeles Dodgers - Sat, Apr 12, 2025 | Away | Dodger Stadium |
| Sun, Apr 13, 2025 | Los Angeles Dodgers | Chicago Cubs vs Los Angeles Dodgers - Sun, Apr 13, 2025 | Away | Dodger Stadium |
| Mon, Apr 14, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Mon, Apr 14, 2025 | Away | Petco Park |
| Tue, Apr 15, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Tue, Apr 15, 2025 | Away | Petco Park |
| Wed, Apr 16, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Wed, Apr 16, 2025 | Away | Petco Park |
| Fri, Apr 18, 2025 | Arizona Diamondbacks | Chicago Cubs vs Arizona Diamondbacks - Fri, Apr 18, 2025 | Home | Wrigley Field |
| Sat, Apr 19, 2025 | Arizona Diamondbacks | Chicago Cubs vs Arizona Diamondbacks - Sat, Apr 19, 2025 | Home | Wrigley Field |
| Sun, Apr 20, 2025 | Arizona Diamondbacks | Chicago Cubs vs Arizona Diamondbacks - Sun, Apr 20, 2025 | Home | Wrigley Field |
| Tue, Apr 22, 2025 | Los Angeles Dodgers | Chicago Cubs vs Los Angeles Dodgers - Tue, Apr 22, 2025 | Home | Wrigley Field |
| Wed, Apr 23, 2025 | Los Angeles Dodgers | Chicago Cubs vs Los Angeles Dodgers - Wed, Apr 23, 2025 | Home | Wrigley Field |
| Fri, Apr 25, 2025 | Philadelphia Phillies | Chicago Cubs vs Philadelphia Phillies - Fri, Apr 25, 2025 | Home | Wrigley Field |
| Sat, Apr 26, 2025 | Philadelphia Phillies | Chicago Cubs vs Philadelphia Phillies - Sat, Apr 26, 2025 | Home | Wrigley Field |
| Sun, Apr 27, 2025 | Philadelphia Phillies | Chicago Cubs vs Philadelphia Phillies - Sun, Apr 27, 2025 | Home | Wrigley Field |
| Tue, Apr 29, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Tue, Apr 29, 2025 | Away | PNC Park |
| Wed, Apr 30, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Wed, Apr 30, 2025 | Away | PNC Park |
| Thu, May 1, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Thu, May 1, 2025 | Away | PNC Park |
| Fri, May 2, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Fri, May 2, 2025 | Away | American Family Field |
| Sat, May 3, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Sat, May 3, 2025 | Away | American Family Field |
| Sun, May 4, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Sun, May 4, 2025 | Away | American Family Field |
| Mon, May 5, 2025 | San Francisco Giants | Chicago Cubs vs San Francisco Giants - Mon, May 5, 2025 | Home | Wrigley Field |
| Tue, May 6, 2025 | San Francisco Giants | Chicago Cubs vs San Francisco Giants - Tue, May 6, 2025 | Home | Wrigley Field |
| Wed, May 7, 2025 | San Francisco Giants | Chicago Cubs vs San Francisco Giants - Wed, May 7, 2025 | Home | Wrigley Field |
| Fri, May 9, 2025 | New York Mets | Chicago Cubs vs New York Mets - Fri, May 9, 2025 | Away | Citi Field |
| Sat, May 10, 2025 | New York Mets | Chicago Cubs vs New York Mets - Sat, May 10, 2025 | Away | Citi Field |
| Sun, May 11, 2025 | New York Mets | Chicago Cubs vs New York Mets - Sun, May 11, 2025 | Away | Citi Field |
| Mon, May 12, 2025 | Miami Marlins | Chicago Cubs vs Miami Marlins - Mon, May 12, 2025 | Home | Wrigley Field |
| Tue, May 13, 2025 | Miami Marlins | Chicago Cubs vs Miami Marlins - Tue, May 13, 2025 | Home | Wrigley Field |
| Wed, May 14, 2025 | Miami Marlins | Chicago Cubs vs Miami Marlins - Wed, May 14, 2025 | Home | Wrigley Field |
| Fri, May 16, 2025 | Chicago White Sox | Chicago Cubs vs Chicago White Sox - Fri, May 16, 2025 | Home | Wrigley Field |
| Sat, May 17, 2025 | Chicago White Sox | Chicago Cubs vs Chicago White Sox - Sat, May 17, 2025 | Home | Wrigley Field |
| Sun, May 18, 2025 | Chicago White Sox | Chicago Cubs vs Chicago White Sox - Sun, May 18, 2025 | Home | Wrigley Field |
| Mon, May 19, 2025 | Miami Marlins | Chicago Cubs vs Miami Marlins - Mon, May 19, 2025 | Away | loanDepot park |
| Tue, May 20, 2025 | Miami Marlins | Chicago Cubs vs Miami Marlins - Tue, May 20, 2025 | Away | loanDepot park |
| Wed, May 21, 2025 | Miami Marlins | Chicago Cubs vs Miami Marlins - Wed, May 21, 2025 | Away | loanDepot park |
| Fri, May 23, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Fri, May 23, 2025 | Away | Great American Ball Park |
| Sat, May 24, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Sat, May 24, 2025 | Away | Great American Ball Park |
| Sun, May 25, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Sun, May 25, 2025 | Away | Great American Ball Park |
| Mon, May 26, 2025 | Colorado Rockies | Chicago Cubs vs Colorado Rockies - Mon, May 26, 2025 | Home | Wrigley Field |
| Tue, May 27, 2025 | Colorado Rockies | Chicago Cubs vs Colorado Rockies - Tue, May 27, 2025 | Home | Wrigley Field |
| Wed, May 28, 2025 | Colorado Rockies | Chicago Cubs vs Colorado Rockies - Wed, May 28, 2025 | Home | Wrigley Field |
| Fri, May 30, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Fri, May 30, 2025 | Home | Wrigley Field |
| Sat, May 31, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Sat, May 31, 2025 | Home | Wrigley Field |
| Sun, Jun 1, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Sun, Jun 1, 2025 | Home | Wrigley Field |
| Tue, Jun 3, 2025 | Washington Nationals | Chicago Cubs vs Washington Nationals - Tue, Jun 3, 2025 | Away | Nationals Park |
| Wed, Jun 4, 2025 | Washington Nationals | Chicago Cubs vs Washington Nationals - Wed, Jun 4, 2025 | Away | Nationals Park |
| Thu, Jun 5, 2025 | Washington Nationals | Chicago Cubs vs Washington Nationals - Thu, Jun 5, 2025 | Away | Nationals Park |
| Fri, Jun 6, 2025 | Detroit Tigers | Chicago Cubs vs Detroit Tigers - Fri, Jun 6, 2025 | Away | Comerica Park |
| Sat, Jun 7, 2025 | Detroit Tigers | Chicago Cubs vs Detroit Tigers - Sat, Jun 7, 2025 | Away | Comerica Park |
| Sun, Jun 8, 2025 | Detroit Tigers | Chicago Cubs vs Detroit Tigers - Sun, Jun 8, 2025 | Away | Comerica Park |
| Mon, Jun 9, 2025 | Philadelphia Phillies | Chicago Cubs vs Philadelphia Phillies - Mon, Jun 9, 2025 | Away | Citizens Bank Park |
| Tue, Jun 10, 2025 | Philadelphia Phillies | Chicago Cubs vs Philadelphia Phillies - Tue, Jun 10, 2025 | Away | Citizens Bank Park |
| Wed, Jun 11, 2025 | Philadelphia Phillies | Chicago Cubs vs Philadelphia Phillies - Wed, Jun 11, 2025 | Away | Citizens Bank Park |
| Thu, Jun 12, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Thu, Jun 12, 2025 | Home | Wrigley Field |
| Fri, Jun 13, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Fri, Jun 13, 2025 | Home | Wrigley Field |
| Sat, Jun 14, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Sat, Jun 14, 2025 | Home | Wrigley Field |
| Sun, Jun 15, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Sun, Jun 15, 2025 | Home | Wrigley Field |
| Tue, Jun 17, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Tue, Jun 17, 2025 | Home | Wrigley Field |
| Thu, Jun 19, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Thu, Jun 19, 2025 | Home | Wrigley Field |
| Fri, Jun 20, 2025 | Seattle Mariners | Chicago Cubs vs Seattle Mariners - Fri, Jun 20, 2025 | Home | Wrigley Field |
| Sat, Jun 21, 2025 | Seattle Mariners | Chicago Cubs vs Seattle Mariners - Sat, Jun 21, 2025 | Home | Wrigley Field |
| Sun, Jun 22, 2025 | Seattle Mariners | Chicago Cubs vs Seattle Mariners - Sun, Jun 22, 2025 | Home | Wrigley Field |
| Mon, Jun 23, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Mon, Jun 23, 2025 | Away | Busch Stadium |
| Tue, Jun 24, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Tue, Jun 24, 2025 | Away | Busch Stadium |
| Wed, Jun 25, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Wed, Jun 25, 2025 | Away | Busch Stadium |
| Thu, Jun 26, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Thu, Jun 26, 2025 | Away | Busch Stadium |
| Fri, Jun 27, 2025 | Houston Astros | Chicago Cubs vs Houston Astros - Fri, Jun 27, 2025 | Away | Daikin Park |
| Sat, Jun 28, 2025 | Houston Astros | Chicago Cubs vs Houston Astros - Sat, Jun 28, 2025 | Away | Daikin Park |
| Sun, Jun 29, 2025 | Houston Astros | Chicago Cubs vs Houston Astros - Sun, Jun 29, 2025 | Away | Daikin Park |
| Tue, Jul 1, 2025 | Cleveland Guardians | Chicago Cubs vs Cleveland Guardians - Tue, Jul 1, 2025 | Home | Wrigley Field |
| Wed, Jul 2, 2025 | Cleveland Guardians | Chicago Cubs vs Cleveland Guardians - Wed, Jul 2, 2025 | Home | Wrigley Field |
| Thu, Jul 3, 2025 | Cleveland Guardians | Chicago Cubs vs Cleveland Guardians - Thu, Jul 3, 2025 | Home | Wrigley Field |
| Fri, Jul 4, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Fri, Jul 4, 2025 | Home | Wrigley Field |
| Sat, Jul 5, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Sat, Jul 5, 2025 | Home | Wrigley Field |
| Sun, Jul 6, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Sun, Jul 6, 2025 | Home | Wrigley Field |
| Tue, Jul 8, 2025 | Minnesota Twins | Chicago Cubs vs Minnesota Twins - Tue, Jul 8, 2025 | Away | Target Field |
| Wed, Jul 9, 2025 | Minnesota Twins | Chicago Cubs vs Minnesota Twins - Wed, Jul 9, 2025 | Away | Target Field |
| Thu, Jul 10, 2025 | Minnesota Twins | Chicago Cubs vs Minnesota Twins - Thu, Jul 10, 2025 | Away | Target Field |
| Fri, Jul 11, 2025 | New York Yankees | Chicago Cubs vs New York Yankees - Fri, Jul 11, 2025 | Away | Yankee Stadium |
| Sat, Jul 12, 2025 | New York Yankees | Chicago Cubs vs New York Yankees - Sat, Jul 12, 2025 | Away | Yankee Stadium |
| Sun, Jul 13, 2025 | New York Yankees | Chicago Cubs vs New York Yankees - Sun, Jul 13, 2025 | Away | Yankee Stadium |
| Fri, Jul 18, 2025 | Boston Red Sox | Chicago Cubs vs Boston Red Sox - Fri, Jul 18, 2025 | Home | Wrigley Field |
| Sat, Jul 19, 2025 | Boston Red Sox | Chicago Cubs vs Boston Red Sox - Sat, Jul 19, 2025 | Home | Wrigley Field |
| Sun, Jul 20, 2025 | Boston Red Sox | Chicago Cubs vs Boston Red Sox - Sun, Jul 20, 2025 | Home | Wrigley Field |
| Mon, Jul 21, 2025 | Kansas City Royals | Chicago Cubs vs Kansas City Royals - Mon, Jul 21, 2025 | Home | Wrigley Field |
| Tue, Jul 22, 2025 | Kansas City Royals | Chicago Cubs vs Kansas City Royals - Tue, Jul 22, 2025 | Home | Wrigley Field |
| Wed, Jul 23, 2025 | Kansas City Royals | Chicago Cubs vs Kansas City Royals - Wed, Jul 23, 2025 | Home | Wrigley Field |
| Fri, Jul 25, 2025 | Chicago White Sox | Chicago Cubs vs Chicago White Sox - Fri, Jul 25, 2025 | Away | Rate Field |
| Sat, Jul 26, 2025 | Chicago White Sox | Chicago Cubs vs Chicago White Sox - Sat, Jul 26, 2025 | Away | Rate Field |
| Sun, Jul 27, 2025 | Chicago White Sox | Chicago Cubs vs Chicago White Sox - Sun, Jul 27, 2025 | Away | Rate Field |
| Mon, Jul 28, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Mon, Jul 28, 2025 | Away | American Family Field |
| Tue, Jul 29, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Tue, Jul 29, 2025 | Away | American Family Field |
| Wed, Jul 30, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Wed, Jul 30, 2025 | Away | American Family Field |
| Fri, Aug 1, 2025 | Baltimore Orioles | Chicago Cubs vs Baltimore Orioles - Fri, Aug 1, 2025 | Home | Wrigley Field |
| Sat, Aug 2, 2025 | Baltimore Orioles | Chicago Cubs vs Baltimore Orioles - Sat, Aug 2, 2025 | Home | Wrigley Field |
| Sun, Aug 3, 2025 | Baltimore Orioles | Chicago Cubs vs Baltimore Orioles - Sun, Aug 3, 2025 | Home | Wrigley Field |
| Mon, Aug 4, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Mon, Aug 4, 2025 | Home | Wrigley Field |
| Tue, Aug 5, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Tue, Aug 5, 2025 | Home | Wrigley Field |
| Wed, Aug 6, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Wed, Aug 6, 2025 | Home | Wrigley Field |
| Fri, Aug 8, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Fri, Aug 8, 2025 | Away | Busch Stadium |
| Sat, Aug 9, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Sat, Aug 9, 2025 | Away | Busch Stadium |
| Sun, Aug 10, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Sun, Aug 10, 2025 | Away | Busch Stadium |
| Tue, Aug 12, 2025 | Toronto Blue Jays | Chicago Cubs vs Toronto Blue Jays - Tue, Aug 12, 2025 | Away | Rogers Centre |
| Wed, Aug 13, 2025 | Toronto Blue Jays | Chicago Cubs vs Toronto Blue Jays - Wed, Aug 13, 2025 | Away | Rogers Centre |
| Thu, Aug 14, 2025 | Toronto Blue Jays | Chicago Cubs vs Toronto Blue Jays - Thu, Aug 14, 2025 | Away | Rogers Centre |
| Fri, Aug 15, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Fri, Aug 15, 2025 | Home | Wrigley Field |
| Sat, Aug 16, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Sat, Aug 16, 2025 | Home | Wrigley Field |
| Sun, Aug 17, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Sun, Aug 17, 2025 | Home | Wrigley Field |
| Mon, Aug 18, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Mon, Aug 18, 2025 | Home | Wrigley Field |
| Tue, Aug 19, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Tue, Aug 19, 2025 | Home | Wrigley Field |
| Tue, Aug 19, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Tue, Aug 19, 2025 | Home | Wrigley Field |
| Wed, Aug 20, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Wed, Aug 20, 2025 | Home | Wrigley Field |
| Thu, Aug 21, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Thu, Aug 21, 2025 | Home | Wrigley Field |
| Fri, Aug 22, 2025 | Los Angeles Angels | Chicago Cubs vs Los Angeles Angels - Fri, Aug 22, 2025 | Away | Angel Stadium |
| Sat, Aug 23, 2025 | Los Angeles Angels | Chicago Cubs vs Los Angeles Angels - Sat, Aug 23, 2025 | Away | Angel Stadium |
| Sun, Aug 24, 2025 | Los Angeles Angels | Chicago Cubs vs Los Angeles Angels - Sun, Aug 24, 2025 | Away | Angel Stadium |
| Tue, Aug 26, 2025 | San Francisco Giants | Chicago Cubs vs San Francisco Giants - Tue, Aug 26, 2025 | Away | Oracle Park |
| Wed, Aug 27, 2025 | San Francisco Giants | Chicago Cubs vs San Francisco Giants - Wed, Aug 27, 2025 | Away | Oracle Park |
| Thu, Aug 28, 2025 | San Francisco Giants | Chicago Cubs vs San Francisco Giants - Thu, Aug 28, 2025 | Away | Oracle Park |
| Fri, Aug 29, 2025 | Colorado Rockies | Chicago Cubs vs Colorado Rockies - Fri, Aug 29, 2025 | Away | Coors Field |
| Sat, Aug 30, 2025 | Colorado Rockies | Chicago Cubs vs Colorado Rockies - Sat, Aug 30, 2025 | Away | Coors Field |
| Sun, Aug 31, 2025 | Colorado Rockies | Chicago Cubs vs Colorado Rockies - Sun, Aug 31, 2025 | Away | Coors Field |
| Mon, Sep 1, 2025 | Atlanta Braves | Chicago Cubs vs Atlanta Braves - Mon, Sep 1, 2025 | Home | Wrigley Field |
| Tue, Sep 2, 2025 | Atlanta Braves | Chicago Cubs vs Atlanta Braves - Tue, Sep 2, 2025 | Home | Wrigley Field |
| Wed, Sep 3, 2025 | Atlanta Braves | Chicago Cubs vs Atlanta Braves - Wed, Sep 3, 2025 | Home | Wrigley Field |
| Fri, Sep 5, 2025 | Washington Nationals | Chicago Cubs vs Washington Nationals - Fri, Sep 5, 2025 | Home | Wrigley Field |
| Sat, Sep 6, 2025 | Washington Nationals | Chicago Cubs vs Washington Nationals - Sat, Sep 6, 2025 | Home | Wrigley Field |
| Sun, Sep 7, 2025 | Washington Nationals | Chicago Cubs vs Washington Nationals - Sun, Sep 7, 2025 | Home | Wrigley Field |
| Mon, Sep 8, 2025 | Atlanta Braves | Chicago Cubs vs Atlanta Braves - Mon, Sep 8, 2025 | Away | Truist Park |
| Tue, Sep 9, 2025 | Atlanta Braves | Chicago Cubs vs Atlanta Braves - Tue, Sep 9, 2025 | Away | Truist Park |
| Wed, Sep 10, 2025 | Atlanta Braves | Chicago Cubs vs Atlanta Braves - Wed, Sep 10, 2025 | Away | Truist Park |
| Fri, Sep 12, 2025 | Tampa Bay Rays | Chicago Cubs vs Tampa Bay Rays - Fri, Sep 12, 2025 | Home | Wrigley Field |
| Sat, Sep 13, 2025 | Tampa Bay Rays | Chicago Cubs vs Tampa Bay Rays - Sat, Sep 13, 2025 | Home | Wrigley Field |
| Sun, Sep 14, 2025 | Tampa Bay Rays | Chicago Cubs vs Tampa Bay Rays - Sun, Sep 14, 2025 | Home | Wrigley Field |
| Mon, Sep 15, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Mon, Sep 15, 2025 | Away | PNC Park |
| Tue, Sep 16, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Tue, Sep 16, 2025 | Away | PNC Park |
| Wed, Sep 17, 2025 | Pittsburgh Pirates | Chicago Cubs vs Pittsburgh Pirates - Wed, Sep 17, 2025 | Away | PNC Park |
| Thu, Sep 18, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Thu, Sep 18, 2025 | Away | Great American Ball Park |
| Fri, Sep 19, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Fri, Sep 19, 2025 | Away | Great American Ball Park |
| Sat, Sep 20, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Sat, Sep 20, 2025 | Away | Great American Ball Park |
| Sun, Sep 21, 2025 | Cincinnati Reds | Chicago Cubs vs Cincinnati Reds - Sun, Sep 21, 2025 | Away | Great American Ball Park |
| Tue, Sep 23, 2025 | New York Mets | Chicago Cubs vs New York Mets - Tue, Sep 23, 2025 | Home | Wrigley Field |
| Wed, Sep 24, 2025 | New York Mets | Chicago Cubs vs New York Mets - Wed, Sep 24, 2025 | Home | Wrigley Field |
| Thu, Sep 25, 2025 | New York Mets | Chicago Cubs vs New York Mets - Thu, Sep 25, 2025 | Home | Wrigley Field |
| Fri, Sep 26, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Fri, Sep 26, 2025 | Home | Wrigley Field |
| Sat, Sep 27, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Sat, Sep 27, 2025 | Home | Wrigley Field |
| Sun, Sep 28, 2025 | St Louis Cardinals | Chicago Cubs vs St Louis Cardinals - Sun, Sep 28, 2025 | Home | Wrigley Field |
| Tue, Sep 30, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Tue, Sep 30, 2025 | Home | Wrigley Field |
| Wed, Oct 1, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Wed, Oct 1, 2025 | Home | Wrigley Field |
| Thu, Oct 2, 2025 | San Diego Padres | Chicago Cubs vs San Diego Padres - Thu, Oct 2, 2025 | Home | Wrigley Field |
| Sat, Oct 4, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Sat, Oct 4, 2025 | Away | American Family Field |
| Mon, Oct 6, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Mon, Oct 6, 2025 | Away | American Family Field |
| Wed, Oct 8, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Wed, Oct 8, 2025 | Home | Wrigley Field |
| Thu, Oct 9, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Thu, Oct 9, 2025 | Home | Wrigley Field |
| Sat, Oct 11, 2025 | Milwaukee Brewers | Chicago Cubs vs Milwaukee Brewers - Sat, Oct 11, 2025 | Away | American Family Field |
