| Sat, Feb 22, 2025 | Washington Nationals | Houston Astros vs Washington Nationals - Sat, Feb 22, 2025 | Home | CACTI Park of the Palm Beaches |
| Sat, Feb 22, 2025 | New York Mets | Houston Astros vs New York Mets - Sat, Feb 22, 2025 | Away | Clover Park |
| Sun, Feb 23, 2025 | St Louis Cardinals | Houston Astros vs St Louis Cardinals - Sun, Feb 23, 2025 | Away | Roger Dean Chevrolet Stadium |
| Mon, Feb 24, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Mon, Feb 24, 2025 | Home | CACTI Park of the Palm Beaches |
| Tue, Feb 25, 2025 | New York Mets | Houston Astros vs New York Mets - Tue, Feb 25, 2025 | Home | CACTI Park of the Palm Beaches |
| Wed, Feb 26, 2025 | Washington Nationals | Houston Astros vs Washington Nationals - Wed, Feb 26, 2025 | Away | CACTI Park of the Palm Beaches |
| Thu, Feb 27, 2025 | New York Mets | Houston Astros vs New York Mets - Thu, Feb 27, 2025 | Away | Clover Park |
| Fri, Feb 28, 2025 | St Louis Cardinals | Houston Astros vs St Louis Cardinals - Fri, Feb 28, 2025 | Home | CACTI Park of the Palm Beaches |
| Sat, Mar 1, 2025 | New York Yankees | Houston Astros vs New York Yankees - Sat, Mar 1, 2025 | Away | George M. Steinbrenner Field |
| Sun, Mar 2, 2025 | Washington Nationals | Houston Astros vs Washington Nationals - Sun, Mar 2, 2025 | Home | CACTI Park of the Palm Beaches |
| Mon, Mar 3, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Mon, Mar 3, 2025 | Away | Roger Dean Chevrolet Stadium |
| Wed, Mar 5, 2025 | St Louis Cardinals | Houston Astros vs St Louis Cardinals - Wed, Mar 5, 2025 | Home | CACTI Park of the Palm Beaches |
| Thu, Mar 6, 2025 | New York Mets | Houston Astros vs New York Mets - Thu, Mar 6, 2025 | Away | Clover Park |
| Fri, Mar 7, 2025 | St Louis Cardinals | Houston Astros vs St Louis Cardinals - Fri, Mar 7, 2025 | Away | Roger Dean Chevrolet Stadium |
| Sat, Mar 8, 2025 | New York Yankees | Houston Astros vs New York Yankees - Sat, Mar 8, 2025 | Home | CACTI Park of the Palm Beaches |
| Sun, Mar 9, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Sun, Mar 9, 2025 | Home | CACTI Park of the Palm Beaches |
| Mon, Mar 10, 2025 | Toronto Blue Jays | Houston Astros vs Toronto Blue Jays - Mon, Mar 10, 2025 | Away | TD Ballpark |
| Tue, Mar 11, 2025 | New York Mets | Houston Astros vs New York Mets - Tue, Mar 11, 2025 | Home | CACTI Park of the Palm Beaches |
| Wed, Mar 12, 2025 | Washington Nationals | Houston Astros vs Washington Nationals - Wed, Mar 12, 2025 | Away | CACTI Park of the Palm Beaches |
| Thu, Mar 13, 2025 | St Louis Cardinals | Houston Astros vs St Louis Cardinals - Thu, Mar 13, 2025 | Home | CACTI Park of the Palm Beaches |
| Thu, Mar 13, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Thu, Mar 13, 2025 | Away | Roger Dean Chevrolet Stadium |
| Fri, Mar 14, 2025 | Toronto Blue Jays | Houston Astros vs Toronto Blue Jays - Fri, Mar 14, 2025 | Home | CACTI Park of the Palm Beaches |
| Sat, Mar 15, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Sat, Mar 15, 2025 | Home | CACTI Park of the Palm Beaches |
| Sun, Mar 16, 2025 | New York Mets | Houston Astros vs New York Mets - Sun, Mar 16, 2025 | Away | Clover Park |
| Tue, Mar 18, 2025 | Washington Nationals | Houston Astros vs Washington Nationals - Tue, Mar 18, 2025 | Home | CACTI Park of the Palm Beaches |
| Wed, Mar 19, 2025 | New York Mets | Houston Astros vs New York Mets - Wed, Mar 19, 2025 | Home | CACTI Park of the Palm Beaches |
| Thu, Mar 20, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Thu, Mar 20, 2025 | Away | Roger Dean Chevrolet Stadium |
| Fri, Mar 21, 2025 | St Louis Cardinals | Houston Astros vs St Louis Cardinals - Fri, Mar 21, 2025 | Away | Roger Dean Chevrolet Stadium |
| Sat, Mar 22, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Sat, Mar 22, 2025 | Home | CACTI Park of the Palm Beaches |
| Sun, Mar 23, 2025 | Washington Nationals | Houston Astros vs Washington Nationals - Sun, Mar 23, 2025 | Away | CACTI Park of the Palm Beaches |
| Thu, Mar 27, 2025 | New York Mets | Houston Astros vs New York Mets - Thu, Mar 27, 2025 | Home | Daikin Park |
| Fri, Mar 28, 2025 | New York Mets | Houston Astros vs New York Mets - Fri, Mar 28, 2025 | Home | Daikin Park |
| Sat, Mar 29, 2025 | New York Mets | Houston Astros vs New York Mets - Sat, Mar 29, 2025 | Home | Daikin Park |
| Mon, Mar 31, 2025 | San Francisco Giants | Houston Astros vs San Francisco Giants - Mon, Mar 31, 2025 | Home | Daikin Park |
| Tue, Apr 1, 2025 | San Francisco Giants | Houston Astros vs San Francisco Giants - Tue, Apr 1, 2025 | Home | Daikin Park |
| Wed, Apr 2, 2025 | San Francisco Giants | Houston Astros vs San Francisco Giants - Wed, Apr 2, 2025 | Home | Daikin Park |
| Thu, Apr 3, 2025 | Minnesota Twins | Houston Astros vs Minnesota Twins - Thu, Apr 3, 2025 | Away | Target Field |
| Sat, Apr 5, 2025 | Minnesota Twins | Houston Astros vs Minnesota Twins - Sat, Apr 5, 2025 | Away | Target Field |
| Sun, Apr 6, 2025 | Minnesota Twins | Houston Astros vs Minnesota Twins - Sun, Apr 6, 2025 | Away | Target Field |
| Mon, Apr 7, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Mon, Apr 7, 2025 | Away | T-Mobile Park |
| Tue, Apr 8, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Tue, Apr 8, 2025 | Away | T-Mobile Park |
| Wed, Apr 9, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Wed, Apr 9, 2025 | Away | T-Mobile Park |
| Fri, Apr 11, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Fri, Apr 11, 2025 | Home | Daikin Park |
| Sat, Apr 12, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Sat, Apr 12, 2025 | Home | Daikin Park |
| Sun, Apr 13, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Sun, Apr 13, 2025 | Home | Daikin Park |
| Mon, Apr 14, 2025 | St Louis Cardinals | Houston Astros vs St Louis Cardinals - Mon, Apr 14, 2025 | Away | Busch Stadium |
| Tue, Apr 15, 2025 | St Louis Cardinals | Houston Astros vs St Louis Cardinals - Tue, Apr 15, 2025 | Away | Busch Stadium |
| Wed, Apr 16, 2025 | St Louis Cardinals | Houston Astros vs St Louis Cardinals - Wed, Apr 16, 2025 | Away | Busch Stadium |
| Fri, Apr 18, 2025 | San Diego Padres | Houston Astros vs San Diego Padres - Fri, Apr 18, 2025 | Home | Daikin Park |
| Sat, Apr 19, 2025 | San Diego Padres | Houston Astros vs San Diego Padres - Sat, Apr 19, 2025 | Home | Daikin Park |
| Sun, Apr 20, 2025 | San Diego Padres | Houston Astros vs San Diego Padres - Sun, Apr 20, 2025 | Home | Daikin Park |
| Mon, Apr 21, 2025 | Toronto Blue Jays | Houston Astros vs Toronto Blue Jays - Mon, Apr 21, 2025 | Home | Daikin Park |
| Tue, Apr 22, 2025 | Toronto Blue Jays | Houston Astros vs Toronto Blue Jays - Tue, Apr 22, 2025 | Home | Daikin Park |
| Wed, Apr 23, 2025 | Toronto Blue Jays | Houston Astros vs Toronto Blue Jays - Wed, Apr 23, 2025 | Home | Daikin Park |
| Fri, Apr 25, 2025 | Kansas City Royals | Houston Astros vs Kansas City Royals - Fri, Apr 25, 2025 | Away | Kauffman Stadium |
| Sat, Apr 26, 2025 | Kansas City Royals | Houston Astros vs Kansas City Royals - Sat, Apr 26, 2025 | Away | Kauffman Stadium |
| Sun, Apr 27, 2025 | Kansas City Royals | Houston Astros vs Kansas City Royals - Sun, Apr 27, 2025 | Away | Kauffman Stadium |
| Mon, Apr 28, 2025 | Detroit Tigers | Houston Astros vs Detroit Tigers - Mon, Apr 28, 2025 | Home | Daikin Park |
| Tue, Apr 29, 2025 | Detroit Tigers | Houston Astros vs Detroit Tigers - Tue, Apr 29, 2025 | Home | Daikin Park |
| Wed, Apr 30, 2025 | Detroit Tigers | Houston Astros vs Detroit Tigers - Wed, Apr 30, 2025 | Home | Daikin Park |
| Fri, May 2, 2025 | Chicago White Sox | Houston Astros vs Chicago White Sox - Fri, May 2, 2025 | Away | Rate Field |
| Sat, May 3, 2025 | Chicago White Sox | Houston Astros vs Chicago White Sox - Sat, May 3, 2025 | Away | Rate Field |
| Sun, May 4, 2025 | Chicago White Sox | Houston Astros vs Chicago White Sox - Sun, May 4, 2025 | Away | Rate Field |
| Mon, May 5, 2025 | Milwaukee Brewers | Houston Astros vs Milwaukee Brewers - Mon, May 5, 2025 | Away | American Family Field |
| Tue, May 6, 2025 | Milwaukee Brewers | Houston Astros vs Milwaukee Brewers - Tue, May 6, 2025 | Away | American Family Field |
| Wed, May 7, 2025 | Milwaukee Brewers | Houston Astros vs Milwaukee Brewers - Wed, May 7, 2025 | Away | American Family Field |
| Fri, May 9, 2025 | Cincinnati Reds | Houston Astros vs Cincinnati Reds - Fri, May 9, 2025 | Home | Daikin Park |
| Sat, May 10, 2025 | Cincinnati Reds | Houston Astros vs Cincinnati Reds - Sat, May 10, 2025 | Home | Daikin Park |
| Sun, May 11, 2025 | Cincinnati Reds | Houston Astros vs Cincinnati Reds - Sun, May 11, 2025 | Home | Daikin Park |
| Mon, May 12, 2025 | Kansas City Royals | Houston Astros vs Kansas City Royals - Mon, May 12, 2025 | Home | Daikin Park |
| Tue, May 13, 2025 | Kansas City Royals | Houston Astros vs Kansas City Royals - Tue, May 13, 2025 | Home | Daikin Park |
| Wed, May 14, 2025 | Kansas City Royals | Houston Astros vs Kansas City Royals - Wed, May 14, 2025 | Home | Daikin Park |
| Thu, May 15, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Thu, May 15, 2025 | Away | Globe Life Field |
| Fri, May 16, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Fri, May 16, 2025 | Away | Globe Life Field |
| Sat, May 17, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Sat, May 17, 2025 | Away | Globe Life Field |
| Sun, May 18, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Sun, May 18, 2025 | Away | Globe Life Field |
| Mon, May 19, 2025 | Tampa Bay Rays | Houston Astros vs Tampa Bay Rays - Mon, May 19, 2025 | Away | George M. Steinbrenner Field |
| Tue, May 20, 2025 | Tampa Bay Rays | Houston Astros vs Tampa Bay Rays - Tue, May 20, 2025 | Away | George M. Steinbrenner Field |
| Wed, May 21, 2025 | Tampa Bay Rays | Houston Astros vs Tampa Bay Rays - Wed, May 21, 2025 | Away | George M. Steinbrenner Field |
| Thu, May 22, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Thu, May 22, 2025 | Home | Daikin Park |
| Fri, May 23, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Fri, May 23, 2025 | Home | Daikin Park |
| Sat, May 24, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Sat, May 24, 2025 | Home | Daikin Park |
| Sun, May 25, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Sun, May 25, 2025 | Home | Daikin Park |
| Tue, May 27, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Tue, May 27, 2025 | Home | Daikin Park |
| Wed, May 28, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Wed, May 28, 2025 | Home | Daikin Park |
| Thu, May 29, 2025 | Tampa Bay Rays | Houston Astros vs Tampa Bay Rays - Thu, May 29, 2025 | Home | Daikin Park |
| Fri, May 30, 2025 | Tampa Bay Rays | Houston Astros vs Tampa Bay Rays - Fri, May 30, 2025 | Home | Daikin Park |
| Sat, May 31, 2025 | Tampa Bay Rays | Houston Astros vs Tampa Bay Rays - Sat, May 31, 2025 | Home | Daikin Park |
| Sun, Jun 1, 2025 | Tampa Bay Rays | Houston Astros vs Tampa Bay Rays - Sun, Jun 1, 2025 | Home | Daikin Park |
| Tue, Jun 3, 2025 | Pittsburgh Pirates | Houston Astros vs Pittsburgh Pirates - Tue, Jun 3, 2025 | Away | PNC Park |
| Wed, Jun 4, 2025 | Pittsburgh Pirates | Houston Astros vs Pittsburgh Pirates - Wed, Jun 4, 2025 | Away | PNC Park |
| Thu, Jun 5, 2025 | Pittsburgh Pirates | Houston Astros vs Pittsburgh Pirates - Thu, Jun 5, 2025 | Away | PNC Park |
| Fri, Jun 6, 2025 | Cleveland Guardians | Houston Astros vs Cleveland Guardians - Fri, Jun 6, 2025 | Away | Progressive Field |
| Sat, Jun 7, 2025 | Cleveland Guardians | Houston Astros vs Cleveland Guardians - Sat, Jun 7, 2025 | Away | Progressive Field |
| Sun, Jun 8, 2025 | Cleveland Guardians | Houston Astros vs Cleveland Guardians - Sun, Jun 8, 2025 | Away | Progressive Field |
| Tue, Jun 10, 2025 | Chicago White Sox | Houston Astros vs Chicago White Sox - Tue, Jun 10, 2025 | Home | Daikin Park |
| Wed, Jun 11, 2025 | Chicago White Sox | Houston Astros vs Chicago White Sox - Wed, Jun 11, 2025 | Home | Daikin Park |
| Thu, Jun 12, 2025 | Chicago White Sox | Houston Astros vs Chicago White Sox - Thu, Jun 12, 2025 | Home | Daikin Park |
| Fri, Jun 13, 2025 | Minnesota Twins | Houston Astros vs Minnesota Twins - Fri, Jun 13, 2025 | Home | Daikin Park |
| Sat, Jun 14, 2025 | Minnesota Twins | Houston Astros vs Minnesota Twins - Sat, Jun 14, 2025 | Home | Daikin Park |
| Sun, Jun 15, 2025 | Minnesota Twins | Houston Astros vs Minnesota Twins - Sun, Jun 15, 2025 | Home | Daikin Park |
| Mon, Jun 16, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Mon, Jun 16, 2025 | Away | Sutter Health Park |
| Tue, Jun 17, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Tue, Jun 17, 2025 | Away | Sutter Health Park |
| Wed, Jun 18, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Wed, Jun 18, 2025 | Away | Sutter Health Park |
| Thu, Jun 19, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Thu, Jun 19, 2025 | Away | Sutter Health Park |
| Fri, Jun 20, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Fri, Jun 20, 2025 | Away | Angel Stadium |
| Sat, Jun 21, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Sat, Jun 21, 2025 | Away | Angel Stadium |
| Sun, Jun 22, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Sun, Jun 22, 2025 | Away | Angel Stadium |
| Tue, Jun 24, 2025 | Philadelphia Phillies | Houston Astros vs Philadelphia Phillies - Tue, Jun 24, 2025 | Home | Daikin Park |
| Wed, Jun 25, 2025 | Philadelphia Phillies | Houston Astros vs Philadelphia Phillies - Wed, Jun 25, 2025 | Home | Daikin Park |
| Thu, Jun 26, 2025 | Philadelphia Phillies | Houston Astros vs Philadelphia Phillies - Thu, Jun 26, 2025 | Home | Daikin Park |
| Fri, Jun 27, 2025 | Chicago Cubs | Houston Astros vs Chicago Cubs - Fri, Jun 27, 2025 | Home | Daikin Park |
| Sat, Jun 28, 2025 | Chicago Cubs | Houston Astros vs Chicago Cubs - Sat, Jun 28, 2025 | Home | Daikin Park |
| Sun, Jun 29, 2025 | Chicago Cubs | Houston Astros vs Chicago Cubs - Sun, Jun 29, 2025 | Home | Daikin Park |
| Tue, Jul 1, 2025 | Colorado Rockies | Houston Astros vs Colorado Rockies - Tue, Jul 1, 2025 | Away | Coors Field |
| Wed, Jul 2, 2025 | Colorado Rockies | Houston Astros vs Colorado Rockies - Wed, Jul 2, 2025 | Away | Coors Field |
| Thu, Jul 3, 2025 | Colorado Rockies | Houston Astros vs Colorado Rockies - Thu, Jul 3, 2025 | Away | Coors Field |
| Fri, Jul 4, 2025 | Los Angeles Dodgers | Houston Astros vs Los Angeles Dodgers - Fri, Jul 4, 2025 | Away | Dodger Stadium |
| Sat, Jul 5, 2025 | Los Angeles Dodgers | Houston Astros vs Los Angeles Dodgers - Sat, Jul 5, 2025 | Away | Dodger Stadium |
| Sun, Jul 6, 2025 | Los Angeles Dodgers | Houston Astros vs Los Angeles Dodgers - Sun, Jul 6, 2025 | Away | Dodger Stadium |
| Mon, Jul 7, 2025 | Cleveland Guardians | Houston Astros vs Cleveland Guardians - Mon, Jul 7, 2025 | Home | Daikin Park |
| Tue, Jul 8, 2025 | Cleveland Guardians | Houston Astros vs Cleveland Guardians - Tue, Jul 8, 2025 | Home | Daikin Park |
| Wed, Jul 9, 2025 | Cleveland Guardians | Houston Astros vs Cleveland Guardians - Wed, Jul 9, 2025 | Home | Daikin Park |
| Fri, Jul 11, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Fri, Jul 11, 2025 | Home | Daikin Park |
| Sat, Jul 12, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Sat, Jul 12, 2025 | Home | Daikin Park |
| Sun, Jul 13, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Sun, Jul 13, 2025 | Home | Daikin Park |
| Fri, Jul 18, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Fri, Jul 18, 2025 | Away | T-Mobile Park |
| Sat, Jul 19, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Sat, Jul 19, 2025 | Away | T-Mobile Park |
| Sun, Jul 20, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Sun, Jul 20, 2025 | Away | T-Mobile Park |
| Mon, Jul 21, 2025 | Arizona Diamondbacks | Houston Astros vs Arizona Diamondbacks - Mon, Jul 21, 2025 | Away | Chase Field |
| Tue, Jul 22, 2025 | Arizona Diamondbacks | Houston Astros vs Arizona Diamondbacks - Tue, Jul 22, 2025 | Away | Chase Field |
| Wed, Jul 23, 2025 | Arizona Diamondbacks | Houston Astros vs Arizona Diamondbacks - Wed, Jul 23, 2025 | Away | Chase Field |
| Thu, Jul 24, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Thu, Jul 24, 2025 | Home | Daikin Park |
| Fri, Jul 25, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Fri, Jul 25, 2025 | Home | Daikin Park |
| Sat, Jul 26, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Sat, Jul 26, 2025 | Home | Daikin Park |
| Sun, Jul 27, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Sun, Jul 27, 2025 | Home | Daikin Park |
| Mon, Jul 28, 2025 | Washington Nationals | Houston Astros vs Washington Nationals - Mon, Jul 28, 2025 | Home | Daikin Park |
| Tue, Jul 29, 2025 | Washington Nationals | Houston Astros vs Washington Nationals - Tue, Jul 29, 2025 | Home | Daikin Park |
| Wed, Jul 30, 2025 | Washington Nationals | Houston Astros vs Washington Nationals - Wed, Jul 30, 2025 | Home | Daikin Park |
| Fri, Aug 1, 2025 | Boston Red Sox | Houston Astros vs Boston Red Sox - Fri, Aug 1, 2025 | Away | Fenway Park |
| Sat, Aug 2, 2025 | Boston Red Sox | Houston Astros vs Boston Red Sox - Sat, Aug 2, 2025 | Away | Fenway Park |
| Sun, Aug 3, 2025 | Boston Red Sox | Houston Astros vs Boston Red Sox - Sun, Aug 3, 2025 | Away | Fenway Park |
| Mon, Aug 4, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Mon, Aug 4, 2025 | Away | loanDepot park |
| Tue, Aug 5, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Tue, Aug 5, 2025 | Away | loanDepot park |
| Wed, Aug 6, 2025 | Miami Marlins | Houston Astros vs Miami Marlins - Wed, Aug 6, 2025 | Away | loanDepot park |
| Fri, Aug 8, 2025 | New York Yankees | Houston Astros vs New York Yankees - Fri, Aug 8, 2025 | Away | Yankee Stadium |
| Sat, Aug 9, 2025 | New York Yankees | Houston Astros vs New York Yankees - Sat, Aug 9, 2025 | Away | Yankee Stadium |
| Sun, Aug 10, 2025 | New York Yankees | Houston Astros vs New York Yankees - Sun, Aug 10, 2025 | Away | Yankee Stadium |
| Mon, Aug 11, 2025 | Boston Red Sox | Houston Astros vs Boston Red Sox - Mon, Aug 11, 2025 | Home | Daikin Park |
| Tue, Aug 12, 2025 | Boston Red Sox | Houston Astros vs Boston Red Sox - Tue, Aug 12, 2025 | Home | Daikin Park |
| Wed, Aug 13, 2025 | Boston Red Sox | Houston Astros vs Boston Red Sox - Wed, Aug 13, 2025 | Home | Daikin Park |
| Fri, Aug 15, 2025 | Baltimore Orioles | Houston Astros vs Baltimore Orioles - Fri, Aug 15, 2025 | Home | Daikin Park |
| Sat, Aug 16, 2025 | Baltimore Orioles | Houston Astros vs Baltimore Orioles - Sat, Aug 16, 2025 | Home | Daikin Park |
| Sun, Aug 17, 2025 | Baltimore Orioles | Houston Astros vs Baltimore Orioles - Sun, Aug 17, 2025 | Home | Daikin Park |
| Mon, Aug 18, 2025 | Detroit Tigers | Houston Astros vs Detroit Tigers - Mon, Aug 18, 2025 | Away | Comerica Park |
| Tue, Aug 19, 2025 | Detroit Tigers | Houston Astros vs Detroit Tigers - Tue, Aug 19, 2025 | Away | Comerica Park |
| Wed, Aug 20, 2025 | Detroit Tigers | Houston Astros vs Detroit Tigers - Wed, Aug 20, 2025 | Away | Comerica Park |
| Thu, Aug 21, 2025 | Baltimore Orioles | Houston Astros vs Baltimore Orioles - Thu, Aug 21, 2025 | Away | Oriole Park at Camden Yards |
| Fri, Aug 22, 2025 | Baltimore Orioles | Houston Astros vs Baltimore Orioles - Fri, Aug 22, 2025 | Away | Oriole Park at Camden Yards |
| Sat, Aug 23, 2025 | Baltimore Orioles | Houston Astros vs Baltimore Orioles - Sat, Aug 23, 2025 | Away | Oriole Park at Camden Yards |
| Sun, Aug 24, 2025 | Baltimore Orioles | Houston Astros vs Baltimore Orioles - Sun, Aug 24, 2025 | Away | Oriole Park at Camden Yards |
| Tue, Aug 26, 2025 | Colorado Rockies | Houston Astros vs Colorado Rockies - Tue, Aug 26, 2025 | Home | Daikin Park |
| Wed, Aug 27, 2025 | Colorado Rockies | Houston Astros vs Colorado Rockies - Wed, Aug 27, 2025 | Home | Daikin Park |
| Thu, Aug 28, 2025 | Colorado Rockies | Houston Astros vs Colorado Rockies - Thu, Aug 28, 2025 | Home | Daikin Park |
| Fri, Aug 29, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Fri, Aug 29, 2025 | Home | Daikin Park |
| Sat, Aug 30, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Sat, Aug 30, 2025 | Home | Daikin Park |
| Sun, Aug 31, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Sun, Aug 31, 2025 | Home | Daikin Park |
| Mon, Sep 1, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Mon, Sep 1, 2025 | Home | Daikin Park |
| Tue, Sep 2, 2025 | New York Yankees | Houston Astros vs New York Yankees - Tue, Sep 2, 2025 | Home | Daikin Park |
| Wed, Sep 3, 2025 | New York Yankees | Houston Astros vs New York Yankees - Wed, Sep 3, 2025 | Home | Daikin Park |
| Thu, Sep 4, 2025 | New York Yankees | Houston Astros vs New York Yankees - Thu, Sep 4, 2025 | Home | Daikin Park |
| Fri, Sep 5, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Fri, Sep 5, 2025 | Away | Globe Life Field |
| Sat, Sep 6, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Sat, Sep 6, 2025 | Away | Globe Life Field |
| Sun, Sep 7, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Sun, Sep 7, 2025 | Away | Globe Life Field |
| Tue, Sep 9, 2025 | Toronto Blue Jays | Houston Astros vs Toronto Blue Jays - Tue, Sep 9, 2025 | Away | Rogers Centre |
| Wed, Sep 10, 2025 | Toronto Blue Jays | Houston Astros vs Toronto Blue Jays - Wed, Sep 10, 2025 | Away | Rogers Centre |
| Thu, Sep 11, 2025 | Toronto Blue Jays | Houston Astros vs Toronto Blue Jays - Thu, Sep 11, 2025 | Away | Rogers Centre |
| Fri, Sep 12, 2025 | Atlanta Braves | Houston Astros vs Atlanta Braves - Fri, Sep 12, 2025 | Away | Truist Park |
| Sat, Sep 13, 2025 | Atlanta Braves | Houston Astros vs Atlanta Braves - Sat, Sep 13, 2025 | Away | Truist Park |
| Sun, Sep 14, 2025 | Atlanta Braves | Houston Astros vs Atlanta Braves - Sun, Sep 14, 2025 | Away | Truist Park |
| Mon, Sep 15, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Mon, Sep 15, 2025 | Home | Daikin Park |
| Tue, Sep 16, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Tue, Sep 16, 2025 | Home | Daikin Park |
| Wed, Sep 17, 2025 | Texas Rangers | Houston Astros vs Texas Rangers - Wed, Sep 17, 2025 | Home | Daikin Park |
| Fri, Sep 19, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Fri, Sep 19, 2025 | Home | Daikin Park |
| Sat, Sep 20, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Sat, Sep 20, 2025 | Home | Daikin Park |
| Sun, Sep 21, 2025 | Seattle Mariners | Houston Astros vs Seattle Mariners - Sun, Sep 21, 2025 | Home | Daikin Park |
| Tue, Sep 23, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Tue, Sep 23, 2025 | Away | Sutter Health Park |
| Wed, Sep 24, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Wed, Sep 24, 2025 | Away | Sutter Health Park |
| Thu, Sep 25, 2025 | Oakland Athletics | Houston Astros vs Oakland Athletics - Thu, Sep 25, 2025 | Away | Sutter Health Park |
| Fri, Sep 26, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Fri, Sep 26, 2025 | Away | Angel Stadium |
| Sat, Sep 27, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Sat, Sep 27, 2025 | Away | Angel Stadium |
| Sun, Sep 28, 2025 | Los Angeles Angels | Houston Astros vs Los Angeles Angels - Sun, Sep 28, 2025 | Away | Angel Stadium |
