| Sat, Feb 22, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Sat, Feb 22, 2025 | Away | Ed Smith Stadium |
| Sun, Feb 23, 2025 | Minnesota Twins | Pittsburgh Pirates vs Minnesota Twins - Sun, Feb 23, 2025 | Home | LECOM Park |
| Mon, Feb 24, 2025 | Philadelphia Phillies | Pittsburgh Pirates vs Philadelphia Phillies - Mon, Feb 24, 2025 | Away | BayCare Ballpark |
| Tue, Feb 25, 2025 | Atlanta Braves | Pittsburgh Pirates vs Atlanta Braves - Tue, Feb 25, 2025 | Home | LECOM Park |
| Wed, Feb 26, 2025 | Atlanta Braves | Pittsburgh Pirates vs Atlanta Braves - Wed, Feb 26, 2025 | Away | CoolToday Park |
| Wed, Feb 26, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Wed, Feb 26, 2025 | Home | LECOM Park |
| Thu, Feb 27, 2025 | Minnesota Twins | Pittsburgh Pirates vs Minnesota Twins - Thu, Feb 27, 2025 | Away | Lee Health Sports Complex |
| Fri, Feb 28, 2025 | Tampa Bay Rays | Pittsburgh Pirates vs Tampa Bay Rays - Fri, Feb 28, 2025 | Home | LECOM Park |
| Sat, Mar 1, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Sat, Mar 1, 2025 | Away | Ed Smith Stadium |
| Sun, Mar 2, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Sun, Mar 2, 2025 | Home | LECOM Park |
| Mon, Mar 3, 2025 | New York Yankees | Pittsburgh Pirates vs New York Yankees - Mon, Mar 3, 2025 | Away | George M. Steinbrenner Field |
| Tue, Mar 4, 2025 | Boston Red Sox | Pittsburgh Pirates vs Boston Red Sox - Tue, Mar 4, 2025 | Home | LECOM Park |
| Wed, Mar 5, 2025 | Toronto Blue Jays | Pittsburgh Pirates vs Toronto Blue Jays - Wed, Mar 5, 2025 | Home | LECOM Park |
| Thu, Mar 6, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Thu, Mar 6, 2025 | Away | Ed Smith Stadium |
| Fri, Mar 7, 2025 | Philadelphia Phillies | Pittsburgh Pirates vs Philadelphia Phillies - Fri, Mar 7, 2025 | Home | LECOM Park |
| Sat, Mar 8, 2025 | Atlanta Braves | Pittsburgh Pirates vs Atlanta Braves - Sat, Mar 8, 2025 | Away | CoolToday Park |
| Sun, Mar 9, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Sun, Mar 9, 2025 | Away | Publix Field at Joker Marchant Stadium |
| Mon, Mar 10, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Mon, Mar 10, 2025 | Home | LECOM Park |
| Tue, Mar 11, 2025 | New York Yankees | Pittsburgh Pirates vs New York Yankees - Tue, Mar 11, 2025 | Home | LECOM Park |
| Thu, Mar 13, 2025 | Minnesota Twins | Pittsburgh Pirates vs Minnesota Twins - Thu, Mar 13, 2025 | Away | Lee Health Sports Complex |
| Fri, Mar 14, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Fri, Mar 14, 2025 | Home | LECOM Park |
| Sat, Mar 15, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Sat, Mar 15, 2025 | Home | LECOM Park |
| Sun, Mar 16, 2025 | New York Yankees | Pittsburgh Pirates vs New York Yankees - Sun, Mar 16, 2025 | Away | George M. Steinbrenner Field |
| Mon, Mar 17, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Mon, Mar 17, 2025 | Away | Publix Field at Joker Marchant Stadium |
| Mon, Mar 17, 2025 | Minnesota Twins | Pittsburgh Pirates vs Minnesota Twins - Mon, Mar 17, 2025 | Home | LECOM Park |
| Tue, Mar 18, 2025 | Philadelphia Phillies | Pittsburgh Pirates vs Philadelphia Phillies - Tue, Mar 18, 2025 | Home | LECOM Park |
| Wed, Mar 19, 2025 | Tampa Bay Rays | Pittsburgh Pirates vs Tampa Bay Rays - Wed, Mar 19, 2025 | Away | Charlotte Sports Park |
| Fri, Mar 21, 2025 | Boston Red Sox | Pittsburgh Pirates vs Boston Red Sox - Fri, Mar 21, 2025 | Away | JetBlue Park |
| Sat, Mar 22, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Sat, Mar 22, 2025 | Home | LECOM Park |
| Sun, Mar 23, 2025 | Toronto Blue Jays | Pittsburgh Pirates vs Toronto Blue Jays - Sun, Mar 23, 2025 | Away | TD Ballpark |
| Mon, Mar 24, 2025 | Minnesota Twins | Pittsburgh Pirates vs Minnesota Twins - Mon, Mar 24, 2025 | Away | Lee Health Sports Complex |
| Thu, Mar 27, 2025 | Miami Marlins | Pittsburgh Pirates vs Miami Marlins - Thu, Mar 27, 2025 | Away | loanDepot park |
| Fri, Mar 28, 2025 | Miami Marlins | Pittsburgh Pirates vs Miami Marlins - Fri, Mar 28, 2025 | Away | loanDepot park |
| Sat, Mar 29, 2025 | Miami Marlins | Pittsburgh Pirates vs Miami Marlins - Sat, Mar 29, 2025 | Away | loanDepot park |
| Sun, Mar 30, 2025 | Miami Marlins | Pittsburgh Pirates vs Miami Marlins - Sun, Mar 30, 2025 | Away | loanDepot park |
| Mon, Mar 31, 2025 | Tampa Bay Rays | Pittsburgh Pirates vs Tampa Bay Rays - Mon, Mar 31, 2025 | Away | George M. Steinbrenner Field |
| Tue, Apr 1, 2025 | Tampa Bay Rays | Pittsburgh Pirates vs Tampa Bay Rays - Tue, Apr 1, 2025 | Away | George M. Steinbrenner Field |
| Wed, Apr 2, 2025 | Tampa Bay Rays | Pittsburgh Pirates vs Tampa Bay Rays - Wed, Apr 2, 2025 | Away | George M. Steinbrenner Field |
| Fri, Apr 4, 2025 | New York Yankees | Pittsburgh Pirates vs New York Yankees - Fri, Apr 4, 2025 | Home | PNC Park |
| Sat, Apr 5, 2025 | New York Yankees | Pittsburgh Pirates vs New York Yankees - Sat, Apr 5, 2025 | Home | PNC Park |
| Sun, Apr 6, 2025 | New York Yankees | Pittsburgh Pirates vs New York Yankees - Sun, Apr 6, 2025 | Home | PNC Park |
| Mon, Apr 7, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Mon, Apr 7, 2025 | Home | PNC Park |
| Tue, Apr 8, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Tue, Apr 8, 2025 | Home | PNC Park |
| Wed, Apr 9, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Wed, Apr 9, 2025 | Home | PNC Park |
| Fri, Apr 11, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Fri, Apr 11, 2025 | Away | Great American Ball Park |
| Sat, Apr 12, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Sat, Apr 12, 2025 | Away | Great American Ball Park |
| Sun, Apr 13, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Sun, Apr 13, 2025 | Away | Great American Ball Park |
| Mon, Apr 14, 2025 | Washington Nationals | Pittsburgh Pirates vs Washington Nationals - Mon, Apr 14, 2025 | Home | PNC Park |
| Tue, Apr 15, 2025 | Washington Nationals | Pittsburgh Pirates vs Washington Nationals - Tue, Apr 15, 2025 | Home | PNC Park |
| Wed, Apr 16, 2025 | Washington Nationals | Pittsburgh Pirates vs Washington Nationals - Wed, Apr 16, 2025 | Home | PNC Park |
| Thu, Apr 17, 2025 | Washington Nationals | Pittsburgh Pirates vs Washington Nationals - Thu, Apr 17, 2025 | Home | PNC Park |
| Fri, Apr 18, 2025 | Cleveland Guardians | Pittsburgh Pirates vs Cleveland Guardians - Fri, Apr 18, 2025 | Home | PNC Park |
| Sat, Apr 19, 2025 | Cleveland Guardians | Pittsburgh Pirates vs Cleveland Guardians - Sat, Apr 19, 2025 | Home | PNC Park |
| Sun, Apr 20, 2025 | Cleveland Guardians | Pittsburgh Pirates vs Cleveland Guardians - Sun, Apr 20, 2025 | Home | PNC Park |
| Tue, Apr 22, 2025 | Los Angeles Angels | Pittsburgh Pirates vs Los Angeles Angels - Tue, Apr 22, 2025 | Away | Angel Stadium |
| Wed, Apr 23, 2025 | Los Angeles Angels | Pittsburgh Pirates vs Los Angeles Angels - Wed, Apr 23, 2025 | Away | Angel Stadium |
| Thu, Apr 24, 2025 | Los Angeles Angels | Pittsburgh Pirates vs Los Angeles Angels - Thu, Apr 24, 2025 | Away | Angel Stadium |
| Fri, Apr 25, 2025 | Los Angeles Dodgers | Pittsburgh Pirates vs Los Angeles Dodgers - Fri, Apr 25, 2025 | Away | Dodger Stadium |
| Sat, Apr 26, 2025 | Los Angeles Dodgers | Pittsburgh Pirates vs Los Angeles Dodgers - Sat, Apr 26, 2025 | Away | Dodger Stadium |
| Sun, Apr 27, 2025 | Los Angeles Dodgers | Pittsburgh Pirates vs Los Angeles Dodgers - Sun, Apr 27, 2025 | Away | Dodger Stadium |
| Tue, Apr 29, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Tue, Apr 29, 2025 | Home | PNC Park |
| Wed, Apr 30, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Wed, Apr 30, 2025 | Home | PNC Park |
| Thu, May 1, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Thu, May 1, 2025 | Home | PNC Park |
| Fri, May 2, 2025 | San Diego Padres | Pittsburgh Pirates vs San Diego Padres - Fri, May 2, 2025 | Home | PNC Park |
| Sat, May 3, 2025 | San Diego Padres | Pittsburgh Pirates vs San Diego Padres - Sat, May 3, 2025 | Home | PNC Park |
| Sun, May 4, 2025 | San Diego Padres | Pittsburgh Pirates vs San Diego Padres - Sun, May 4, 2025 | Home | PNC Park |
| Mon, May 5, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Mon, May 5, 2025 | Away | Busch Stadium |
| Tue, May 6, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Tue, May 6, 2025 | Away | Busch Stadium |
| Wed, May 7, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Wed, May 7, 2025 | Away | Busch Stadium |
| Fri, May 9, 2025 | Atlanta Braves | Pittsburgh Pirates vs Atlanta Braves - Fri, May 9, 2025 | Home | PNC Park |
| Sat, May 10, 2025 | Atlanta Braves | Pittsburgh Pirates vs Atlanta Braves - Sat, May 10, 2025 | Home | PNC Park |
| Sun, May 11, 2025 | Atlanta Braves | Pittsburgh Pirates vs Atlanta Braves - Sun, May 11, 2025 | Home | PNC Park |
| Mon, May 12, 2025 | New York Mets | Pittsburgh Pirates vs New York Mets - Mon, May 12, 2025 | Away | Citi Field |
| Tue, May 13, 2025 | New York Mets | Pittsburgh Pirates vs New York Mets - Tue, May 13, 2025 | Away | Citi Field |
| Wed, May 14, 2025 | New York Mets | Pittsburgh Pirates vs New York Mets - Wed, May 14, 2025 | Away | Citi Field |
| Fri, May 16, 2025 | Philadelphia Phillies | Pittsburgh Pirates vs Philadelphia Phillies - Fri, May 16, 2025 | Away | Citizens Bank Park |
| Sat, May 17, 2025 | Philadelphia Phillies | Pittsburgh Pirates vs Philadelphia Phillies - Sat, May 17, 2025 | Away | Citizens Bank Park |
| Sun, May 18, 2025 | Philadelphia Phillies | Pittsburgh Pirates vs Philadelphia Phillies - Sun, May 18, 2025 | Away | Citizens Bank Park |
| Mon, May 19, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Mon, May 19, 2025 | Home | PNC Park |
| Tue, May 20, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Tue, May 20, 2025 | Home | PNC Park |
| Wed, May 21, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Wed, May 21, 2025 | Home | PNC Park |
| Thu, May 22, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Thu, May 22, 2025 | Home | PNC Park |
| Fri, May 23, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Fri, May 23, 2025 | Home | PNC Park |
| Sat, May 24, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Sat, May 24, 2025 | Home | PNC Park |
| Sun, May 25, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Sun, May 25, 2025 | Home | PNC Park |
| Mon, May 26, 2025 | Arizona Diamondbacks | Pittsburgh Pirates vs Arizona Diamondbacks - Mon, May 26, 2025 | Away | Chase Field |
| Tue, May 27, 2025 | Arizona Diamondbacks | Pittsburgh Pirates vs Arizona Diamondbacks - Tue, May 27, 2025 | Away | Chase Field |
| Wed, May 28, 2025 | Arizona Diamondbacks | Pittsburgh Pirates vs Arizona Diamondbacks - Wed, May 28, 2025 | Away | Chase Field |
| Fri, May 30, 2025 | San Diego Padres | Pittsburgh Pirates vs San Diego Padres - Fri, May 30, 2025 | Away | Petco Park |
| Sat, May 31, 2025 | San Diego Padres | Pittsburgh Pirates vs San Diego Padres - Sat, May 31, 2025 | Away | Petco Park |
| Sun, Jun 1, 2025 | San Diego Padres | Pittsburgh Pirates vs San Diego Padres - Sun, Jun 1, 2025 | Away | Petco Park |
| Tue, Jun 3, 2025 | Houston Astros | Pittsburgh Pirates vs Houston Astros - Tue, Jun 3, 2025 | Home | PNC Park |
| Wed, Jun 4, 2025 | Houston Astros | Pittsburgh Pirates vs Houston Astros - Wed, Jun 4, 2025 | Home | PNC Park |
| Thu, Jun 5, 2025 | Houston Astros | Pittsburgh Pirates vs Houston Astros - Thu, Jun 5, 2025 | Home | PNC Park |
| Fri, Jun 6, 2025 | Philadelphia Phillies | Pittsburgh Pirates vs Philadelphia Phillies - Fri, Jun 6, 2025 | Home | PNC Park |
| Sat, Jun 7, 2025 | Philadelphia Phillies | Pittsburgh Pirates vs Philadelphia Phillies - Sat, Jun 7, 2025 | Home | PNC Park |
| Sun, Jun 8, 2025 | Philadelphia Phillies | Pittsburgh Pirates vs Philadelphia Phillies - Sun, Jun 8, 2025 | Home | PNC Park |
| Mon, Jun 9, 2025 | Miami Marlins | Pittsburgh Pirates vs Miami Marlins - Mon, Jun 9, 2025 | Home | PNC Park |
| Tue, Jun 10, 2025 | Miami Marlins | Pittsburgh Pirates vs Miami Marlins - Tue, Jun 10, 2025 | Home | PNC Park |
| Wed, Jun 11, 2025 | Miami Marlins | Pittsburgh Pirates vs Miami Marlins - Wed, Jun 11, 2025 | Home | PNC Park |
| Thu, Jun 12, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Thu, Jun 12, 2025 | Away | Wrigley Field |
| Fri, Jun 13, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Fri, Jun 13, 2025 | Away | Wrigley Field |
| Sat, Jun 14, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Sat, Jun 14, 2025 | Away | Wrigley Field |
| Sun, Jun 15, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Sun, Jun 15, 2025 | Away | Wrigley Field |
| Tue, Jun 17, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Tue, Jun 17, 2025 | Away | Comerica Park |
| Thu, Jun 19, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Thu, Jun 19, 2025 | Away | Comerica Park |
| Thu, Jun 19, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Thu, Jun 19, 2025 | Away | Comerica Park |
| Fri, Jun 20, 2025 | Texas Rangers | Pittsburgh Pirates vs Texas Rangers - Fri, Jun 20, 2025 | Home | PNC Park |
| Sat, Jun 21, 2025 | Texas Rangers | Pittsburgh Pirates vs Texas Rangers - Sat, Jun 21, 2025 | Home | PNC Park |
| Sun, Jun 22, 2025 | Texas Rangers | Pittsburgh Pirates vs Texas Rangers - Sun, Jun 22, 2025 | Home | PNC Park |
| Mon, Jun 23, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Mon, Jun 23, 2025 | Away | American Family Field |
| Tue, Jun 24, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Tue, Jun 24, 2025 | Away | American Family Field |
| Wed, Jun 25, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Wed, Jun 25, 2025 | Away | American Family Field |
| Fri, Jun 27, 2025 | New York Mets | Pittsburgh Pirates vs New York Mets - Fri, Jun 27, 2025 | Home | PNC Park |
| Sat, Jun 28, 2025 | New York Mets | Pittsburgh Pirates vs New York Mets - Sat, Jun 28, 2025 | Home | PNC Park |
| Sun, Jun 29, 2025 | New York Mets | Pittsburgh Pirates vs New York Mets - Sun, Jun 29, 2025 | Home | PNC Park |
| Mon, Jun 30, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Mon, Jun 30, 2025 | Home | PNC Park |
| Tue, Jul 1, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Tue, Jul 1, 2025 | Home | PNC Park |
| Wed, Jul 2, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Wed, Jul 2, 2025 | Home | PNC Park |
| Fri, Jul 4, 2025 | Seattle Mariners | Pittsburgh Pirates vs Seattle Mariners - Fri, Jul 4, 2025 | Away | T-Mobile Park |
| Sat, Jul 5, 2025 | Seattle Mariners | Pittsburgh Pirates vs Seattle Mariners - Sat, Jul 5, 2025 | Away | T-Mobile Park |
| Sun, Jul 6, 2025 | Seattle Mariners | Pittsburgh Pirates vs Seattle Mariners - Sun, Jul 6, 2025 | Away | T-Mobile Park |
| Mon, Jul 7, 2025 | Kansas City Royals | Pittsburgh Pirates vs Kansas City Royals - Mon, Jul 7, 2025 | Away | Kauffman Stadium |
| Tue, Jul 8, 2025 | Kansas City Royals | Pittsburgh Pirates vs Kansas City Royals - Tue, Jul 8, 2025 | Away | Kauffman Stadium |
| Wed, Jul 9, 2025 | Kansas City Royals | Pittsburgh Pirates vs Kansas City Royals - Wed, Jul 9, 2025 | Away | Kauffman Stadium |
| Fri, Jul 11, 2025 | Minnesota Twins | Pittsburgh Pirates vs Minnesota Twins - Fri, Jul 11, 2025 | Away | Target Field |
| Sat, Jul 12, 2025 | Minnesota Twins | Pittsburgh Pirates vs Minnesota Twins - Sat, Jul 12, 2025 | Away | Target Field |
| Sun, Jul 13, 2025 | Minnesota Twins | Pittsburgh Pirates vs Minnesota Twins - Sun, Jul 13, 2025 | Away | Target Field |
| Fri, Jul 18, 2025 | Chicago White Sox | Pittsburgh Pirates vs Chicago White Sox - Fri, Jul 18, 2025 | Home | PNC Park |
| Sat, Jul 19, 2025 | Chicago White Sox | Pittsburgh Pirates vs Chicago White Sox - Sat, Jul 19, 2025 | Home | PNC Park |
| Sun, Jul 20, 2025 | Chicago White Sox | Pittsburgh Pirates vs Chicago White Sox - Sun, Jul 20, 2025 | Home | PNC Park |
| Mon, Jul 21, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Mon, Jul 21, 2025 | Home | PNC Park |
| Tue, Jul 22, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Tue, Jul 22, 2025 | Home | PNC Park |
| Wed, Jul 23, 2025 | Detroit Tigers | Pittsburgh Pirates vs Detroit Tigers - Wed, Jul 23, 2025 | Home | PNC Park |
| Fri, Jul 25, 2025 | Arizona Diamondbacks | Pittsburgh Pirates vs Arizona Diamondbacks - Fri, Jul 25, 2025 | Home | PNC Park |
| Sat, Jul 26, 2025 | Arizona Diamondbacks | Pittsburgh Pirates vs Arizona Diamondbacks - Sat, Jul 26, 2025 | Home | PNC Park |
| Sun, Jul 27, 2025 | Arizona Diamondbacks | Pittsburgh Pirates vs Arizona Diamondbacks - Sun, Jul 27, 2025 | Home | PNC Park |
| Mon, Jul 28, 2025 | San Francisco Giants | Pittsburgh Pirates vs San Francisco Giants - Mon, Jul 28, 2025 | Away | Oracle Park |
| Tue, Jul 29, 2025 | San Francisco Giants | Pittsburgh Pirates vs San Francisco Giants - Tue, Jul 29, 2025 | Away | Oracle Park |
| Wed, Jul 30, 2025 | San Francisco Giants | Pittsburgh Pirates vs San Francisco Giants - Wed, Jul 30, 2025 | Away | Oracle Park |
| Fri, Aug 1, 2025 | Colorado Rockies | Pittsburgh Pirates vs Colorado Rockies - Fri, Aug 1, 2025 | Away | Coors Field |
| Sat, Aug 2, 2025 | Colorado Rockies | Pittsburgh Pirates vs Colorado Rockies - Sat, Aug 2, 2025 | Away | Coors Field |
| Sun, Aug 3, 2025 | Colorado Rockies | Pittsburgh Pirates vs Colorado Rockies - Sun, Aug 3, 2025 | Away | Coors Field |
| Mon, Aug 4, 2025 | San Francisco Giants | Pittsburgh Pirates vs San Francisco Giants - Mon, Aug 4, 2025 | Home | PNC Park |
| Tue, Aug 5, 2025 | San Francisco Giants | Pittsburgh Pirates vs San Francisco Giants - Tue, Aug 5, 2025 | Home | PNC Park |
| Wed, Aug 6, 2025 | San Francisco Giants | Pittsburgh Pirates vs San Francisco Giants - Wed, Aug 6, 2025 | Home | PNC Park |
| Thu, Aug 7, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Thu, Aug 7, 2025 | Home | PNC Park |
| Fri, Aug 8, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Fri, Aug 8, 2025 | Home | PNC Park |
| Sat, Aug 9, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Sat, Aug 9, 2025 | Home | PNC Park |
| Sun, Aug 10, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Sun, Aug 10, 2025 | Home | PNC Park |
| Mon, Aug 11, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Mon, Aug 11, 2025 | Away | American Family Field |
| Tue, Aug 12, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Tue, Aug 12, 2025 | Away | American Family Field |
| Wed, Aug 13, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Wed, Aug 13, 2025 | Away | American Family Field |
| Fri, Aug 15, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Fri, Aug 15, 2025 | Away | Wrigley Field |
| Sat, Aug 16, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Sat, Aug 16, 2025 | Away | Wrigley Field |
| Sun, Aug 17, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Sun, Aug 17, 2025 | Away | Wrigley Field |
| Mon, Aug 18, 2025 | Toronto Blue Jays | Pittsburgh Pirates vs Toronto Blue Jays - Mon, Aug 18, 2025 | Home | PNC Park |
| Tue, Aug 19, 2025 | Toronto Blue Jays | Pittsburgh Pirates vs Toronto Blue Jays - Tue, Aug 19, 2025 | Home | PNC Park |
| Wed, Aug 20, 2025 | Toronto Blue Jays | Pittsburgh Pirates vs Toronto Blue Jays - Wed, Aug 20, 2025 | Home | PNC Park |
| Fri, Aug 22, 2025 | Colorado Rockies | Pittsburgh Pirates vs Colorado Rockies - Fri, Aug 22, 2025 | Home | PNC Park |
| Sat, Aug 23, 2025 | Colorado Rockies | Pittsburgh Pirates vs Colorado Rockies - Sat, Aug 23, 2025 | Home | PNC Park |
| Sun, Aug 24, 2025 | Colorado Rockies | Pittsburgh Pirates vs Colorado Rockies - Sun, Aug 24, 2025 | Home | PNC Park |
| Mon, Aug 25, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Mon, Aug 25, 2025 | Away | Busch Stadium |
| Tue, Aug 26, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Tue, Aug 26, 2025 | Away | Busch Stadium |
| Wed, Aug 27, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Wed, Aug 27, 2025 | Away | Busch Stadium |
| Thu, Aug 28, 2025 | St Louis Cardinals | Pittsburgh Pirates vs St Louis Cardinals - Thu, Aug 28, 2025 | Away | Busch Stadium |
| Fri, Aug 29, 2025 | Boston Red Sox | Pittsburgh Pirates vs Boston Red Sox - Fri, Aug 29, 2025 | Away | Fenway Park |
| Sat, Aug 30, 2025 | Boston Red Sox | Pittsburgh Pirates vs Boston Red Sox - Sat, Aug 30, 2025 | Away | Fenway Park |
| Sun, Aug 31, 2025 | Boston Red Sox | Pittsburgh Pirates vs Boston Red Sox - Sun, Aug 31, 2025 | Away | Fenway Park |
| Tue, Sep 2, 2025 | Los Angeles Dodgers | Pittsburgh Pirates vs Los Angeles Dodgers - Tue, Sep 2, 2025 | Home | PNC Park |
| Wed, Sep 3, 2025 | Los Angeles Dodgers | Pittsburgh Pirates vs Los Angeles Dodgers - Wed, Sep 3, 2025 | Home | PNC Park |
| Thu, Sep 4, 2025 | Los Angeles Dodgers | Pittsburgh Pirates vs Los Angeles Dodgers - Thu, Sep 4, 2025 | Home | PNC Park |
| Fri, Sep 5, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Fri, Sep 5, 2025 | Home | PNC Park |
| Sat, Sep 6, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Sat, Sep 6, 2025 | Home | PNC Park |
| Sun, Sep 7, 2025 | Milwaukee Brewers | Pittsburgh Pirates vs Milwaukee Brewers - Sun, Sep 7, 2025 | Home | PNC Park |
| Tue, Sep 9, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Tue, Sep 9, 2025 | Away | Oriole Park at Camden Yards |
| Wed, Sep 10, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Wed, Sep 10, 2025 | Away | Oriole Park at Camden Yards |
| Thu, Sep 11, 2025 | Baltimore Orioles | Pittsburgh Pirates vs Baltimore Orioles - Thu, Sep 11, 2025 | Away | Oriole Park at Camden Yards |
| Fri, Sep 12, 2025 | Washington Nationals | Pittsburgh Pirates vs Washington Nationals - Fri, Sep 12, 2025 | Away | Nationals Park |
| Sat, Sep 13, 2025 | Washington Nationals | Pittsburgh Pirates vs Washington Nationals - Sat, Sep 13, 2025 | Away | Nationals Park |
| Sun, Sep 14, 2025 | Washington Nationals | Pittsburgh Pirates vs Washington Nationals - Sun, Sep 14, 2025 | Away | Nationals Park |
| Mon, Sep 15, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Mon, Sep 15, 2025 | Home | PNC Park |
| Tue, Sep 16, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Tue, Sep 16, 2025 | Home | PNC Park |
| Wed, Sep 17, 2025 | Chicago Cubs | Pittsburgh Pirates vs Chicago Cubs - Wed, Sep 17, 2025 | Home | PNC Park |
| Fri, Sep 19, 2025 | Oakland Athletics | Pittsburgh Pirates vs Oakland Athletics - Fri, Sep 19, 2025 | Home | PNC Park |
| Sat, Sep 20, 2025 | Oakland Athletics | Pittsburgh Pirates vs Oakland Athletics - Sat, Sep 20, 2025 | Home | PNC Park |
| Sun, Sep 21, 2025 | Oakland Athletics | Pittsburgh Pirates vs Oakland Athletics - Sun, Sep 21, 2025 | Home | PNC Park |
| Tue, Sep 23, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Tue, Sep 23, 2025 | Away | Great American Ball Park |
| Wed, Sep 24, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Wed, Sep 24, 2025 | Away | Great American Ball Park |
| Thu, Sep 25, 2025 | Cincinnati Reds | Pittsburgh Pirates vs Cincinnati Reds - Thu, Sep 25, 2025 | Away | Great American Ball Park |
| Fri, Sep 26, 2025 | Atlanta Braves | Pittsburgh Pirates vs Atlanta Braves - Fri, Sep 26, 2025 | Away | Truist Park |
| Sat, Sep 27, 2025 | Atlanta Braves | Pittsburgh Pirates vs Atlanta Braves - Sat, Sep 27, 2025 | Away | Truist Park |
| Sun, Sep 28, 2025 | Atlanta Braves | Pittsburgh Pirates vs Atlanta Braves - Sun, Sep 28, 2025 | Away | Truist Park |
