| Sat, Feb 22, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Sat, Feb 22, 2025 | Away | Charlotte Sports Park |
| Sun, Feb 23, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Sun, Feb 23, 2025 | Home | JetBlue Park |
| Mon, Feb 24, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Mon, Feb 24, 2025 | Home | JetBlue Park |
| Tue, Feb 25, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Tue, Feb 25, 2025 | Away | CoolToday Park |
| Wed, Feb 26, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Wed, Feb 26, 2025 | Home | JetBlue Park |
| Thu, Feb 27, 2025 | Detroit Tigers | Boston Red Sox vs Detroit Tigers - Thu, Feb 27, 2025 | Away | Publix Field at Joker Marchant Stadium |
| Fri, Feb 28, 2025 | Philadelphia Phillies | Boston Red Sox vs Philadelphia Phillies - Fri, Feb 28, 2025 | Away | BayCare Ballpark |
| Sat, Mar 1, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Sat, Mar 1, 2025 | Home | JetBlue Park |
| Sun, Mar 2, 2025 | New York Mets | Boston Red Sox vs New York Mets - Sun, Mar 2, 2025 | Home | JetBlue Park |
| Mon, Mar 3, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Mon, Mar 3, 2025 | Away | Ed Smith Stadium |
| Tue, Mar 4, 2025 | Pittsburgh Pirates | Boston Red Sox vs Pittsburgh Pirates - Tue, Mar 4, 2025 | Away | LECOM Park |
| Wed, Mar 5, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Wed, Mar 5, 2025 | Home | JetBlue Park |
| Thu, Mar 6, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Thu, Mar 6, 2025 | Away | TD Ballpark |
| Fri, Mar 7, 2025 | Miami Marlins | Boston Red Sox vs Miami Marlins - Fri, Mar 7, 2025 | Home | JetBlue Park |
| Sat, Mar 8, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Sat, Mar 8, 2025 | Away | Lee Health Sports Complex |
| Sun, Mar 9, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Sun, Mar 9, 2025 | Home | JetBlue Park |
| Tue, Mar 11, 2025 | Philadelphia Phillies | Boston Red Sox vs Philadelphia Phillies - Tue, Mar 11, 2025 | Home | JetBlue Park |
| Wed, Mar 12, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Wed, Mar 12, 2025 | Home | JetBlue Park |
| Thu, Mar 13, 2025 | New York Mets | Boston Red Sox vs New York Mets - Thu, Mar 13, 2025 | Away | Clover Park |
| Fri, Mar 14, 2025 | Miami Marlins | Boston Red Sox vs Miami Marlins - Fri, Mar 14, 2025 | Away | Roger Dean Chevrolet Stadium |
| Sat, Mar 15, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Sat, Mar 15, 2025 | Home | JetBlue Park |
| Sun, Mar 16, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Sun, Mar 16, 2025 | Away | Lee Health Sports Complex |
| Mon, Mar 17, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Mon, Mar 17, 2025 | Away | CoolToday Park |
| Mon, Mar 17, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Mon, Mar 17, 2025 | Home | JetBlue Park |
| Tue, Mar 18, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Tue, Mar 18, 2025 | Away | George M. Steinbrenner Field |
| Wed, Mar 19, 2025 | Detroit Tigers | Boston Red Sox vs Detroit Tigers - Wed, Mar 19, 2025 | Home | JetBlue Park |
| Thu, Mar 20, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Thu, Mar 20, 2025 | Away | Lee Health Sports Complex |
| Fri, Mar 21, 2025 | Pittsburgh Pirates | Boston Red Sox vs Pittsburgh Pirates - Fri, Mar 21, 2025 | Home | JetBlue Park |
| Sat, Mar 22, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Sat, Mar 22, 2025 | Away | Charlotte Sports Park |
| Sun, Mar 23, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Sun, Mar 23, 2025 | Home | JetBlue Park |
| Thu, Mar 27, 2025 | Texas Rangers | Boston Red Sox vs Texas Rangers - Thu, Mar 27, 2025 | Away | Globe Life Field |
| Fri, Mar 28, 2025 | Texas Rangers | Boston Red Sox vs Texas Rangers - Fri, Mar 28, 2025 | Away | Globe Life Field |
| Sat, Mar 29, 2025 | Texas Rangers | Boston Red Sox vs Texas Rangers - Sat, Mar 29, 2025 | Away | Globe Life Field |
| Sun, Mar 30, 2025 | Texas Rangers | Boston Red Sox vs Texas Rangers - Sun, Mar 30, 2025 | Away | Globe Life Field |
| Mon, Mar 31, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Mon, Mar 31, 2025 | Away | Oriole Park at Camden Yards |
| Wed, Apr 2, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Wed, Apr 2, 2025 | Away | Oriole Park at Camden Yards |
| Thu, Apr 3, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Thu, Apr 3, 2025 | Away | Oriole Park at Camden Yards |
| Fri, Apr 4, 2025 | St Louis Cardinals | Boston Red Sox vs St Louis Cardinals - Fri, Apr 4, 2025 | Home | Fenway Park |
| Sun, Apr 6, 2025 | St Louis Cardinals | Boston Red Sox vs St Louis Cardinals - Sun, Apr 6, 2025 | Home | Fenway Park |
| Sun, Apr 6, 2025 | St Louis Cardinals | Boston Red Sox vs St Louis Cardinals - Sun, Apr 6, 2025 | Home | Fenway Park |
| Mon, Apr 7, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Mon, Apr 7, 2025 | Home | Fenway Park |
| Tue, Apr 8, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Tue, Apr 8, 2025 | Home | Fenway Park |
| Wed, Apr 9, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Wed, Apr 9, 2025 | Home | Fenway Park |
| Thu, Apr 10, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Thu, Apr 10, 2025 | Home | Fenway Park |
| Fri, Apr 11, 2025 | Chicago White Sox | Boston Red Sox vs Chicago White Sox - Fri, Apr 11, 2025 | Away | Rate Field |
| Sat, Apr 12, 2025 | Chicago White Sox | Boston Red Sox vs Chicago White Sox - Sat, Apr 12, 2025 | Away | Rate Field |
| Sun, Apr 13, 2025 | Chicago White Sox | Boston Red Sox vs Chicago White Sox - Sun, Apr 13, 2025 | Away | Rate Field |
| Mon, Apr 14, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Mon, Apr 14, 2025 | Away | George M. Steinbrenner Field |
| Tue, Apr 15, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Tue, Apr 15, 2025 | Away | George M. Steinbrenner Field |
| Wed, Apr 16, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Wed, Apr 16, 2025 | Away | George M. Steinbrenner Field |
| Fri, Apr 18, 2025 | Chicago White Sox | Boston Red Sox vs Chicago White Sox - Fri, Apr 18, 2025 | Home | Fenway Park |
| Sat, Apr 19, 2025 | Chicago White Sox | Boston Red Sox vs Chicago White Sox - Sat, Apr 19, 2025 | Home | Fenway Park |
| Sun, Apr 20, 2025 | Chicago White Sox | Boston Red Sox vs Chicago White Sox - Sun, Apr 20, 2025 | Home | Fenway Park |
| Mon, Apr 21, 2025 | Chicago White Sox | Boston Red Sox vs Chicago White Sox - Mon, Apr 21, 2025 | Home | Fenway Park |
| Tue, Apr 22, 2025 | Seattle Mariners | Boston Red Sox vs Seattle Mariners - Tue, Apr 22, 2025 | Home | Fenway Park |
| Wed, Apr 23, 2025 | Seattle Mariners | Boston Red Sox vs Seattle Mariners - Wed, Apr 23, 2025 | Home | Fenway Park |
| Thu, Apr 24, 2025 | Seattle Mariners | Boston Red Sox vs Seattle Mariners - Thu, Apr 24, 2025 | Home | Fenway Park |
| Sat, Apr 26, 2025 | Cleveland Guardians | Boston Red Sox vs Cleveland Guardians - Sat, Apr 26, 2025 | Away | Progressive Field |
| Sat, Apr 26, 2025 | Cleveland Guardians | Boston Red Sox vs Cleveland Guardians - Sat, Apr 26, 2025 | Away | Progressive Field |
| Sun, Apr 27, 2025 | Cleveland Guardians | Boston Red Sox vs Cleveland Guardians - Sun, Apr 27, 2025 | Away | Progressive Field |
| Tue, Apr 29, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Tue, Apr 29, 2025 | Away | Rogers Centre |
| Wed, Apr 30, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Wed, Apr 30, 2025 | Away | Rogers Centre |
| Thu, May 1, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Thu, May 1, 2025 | Away | Rogers Centre |
| Fri, May 2, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Fri, May 2, 2025 | Home | Fenway Park |
| Sat, May 3, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Sat, May 3, 2025 | Home | Fenway Park |
| Sun, May 4, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Sun, May 4, 2025 | Home | Fenway Park |
| Tue, May 6, 2025 | Texas Rangers | Boston Red Sox vs Texas Rangers - Tue, May 6, 2025 | Home | Fenway Park |
| Wed, May 7, 2025 | Texas Rangers | Boston Red Sox vs Texas Rangers - Wed, May 7, 2025 | Home | Fenway Park |
| Thu, May 8, 2025 | Texas Rangers | Boston Red Sox vs Texas Rangers - Thu, May 8, 2025 | Home | Fenway Park |
| Fri, May 9, 2025 | Kansas City Royals | Boston Red Sox vs Kansas City Royals - Fri, May 9, 2025 | Away | Kauffman Stadium |
| Sat, May 10, 2025 | Kansas City Royals | Boston Red Sox vs Kansas City Royals - Sat, May 10, 2025 | Away | Kauffman Stadium |
| Sun, May 11, 2025 | Kansas City Royals | Boston Red Sox vs Kansas City Royals - Sun, May 11, 2025 | Away | Kauffman Stadium |
| Mon, May 12, 2025 | Detroit Tigers | Boston Red Sox vs Detroit Tigers - Mon, May 12, 2025 | Away | Comerica Park |
| Tue, May 13, 2025 | Detroit Tigers | Boston Red Sox vs Detroit Tigers - Tue, May 13, 2025 | Away | Comerica Park |
| Wed, May 14, 2025 | Detroit Tigers | Boston Red Sox vs Detroit Tigers - Wed, May 14, 2025 | Away | Comerica Park |
| Fri, May 16, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Fri, May 16, 2025 | Home | Fenway Park |
| Sat, May 17, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Sat, May 17, 2025 | Home | Fenway Park |
| Sun, May 18, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Sun, May 18, 2025 | Home | Fenway Park |
| Mon, May 19, 2025 | New York Mets | Boston Red Sox vs New York Mets - Mon, May 19, 2025 | Home | Fenway Park |
| Tue, May 20, 2025 | New York Mets | Boston Red Sox vs New York Mets - Tue, May 20, 2025 | Home | Fenway Park |
| Wed, May 21, 2025 | New York Mets | Boston Red Sox vs New York Mets - Wed, May 21, 2025 | Home | Fenway Park |
| Fri, May 23, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Fri, May 23, 2025 | Home | Fenway Park |
| Sat, May 24, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Sat, May 24, 2025 | Home | Fenway Park |
| Sat, May 24, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Sat, May 24, 2025 | Home | Fenway Park |
| Sun, May 25, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Sun, May 25, 2025 | Home | Fenway Park |
| Mon, May 26, 2025 | Milwaukee Brewers | Boston Red Sox vs Milwaukee Brewers - Mon, May 26, 2025 | Away | American Family Field |
| Tue, May 27, 2025 | Milwaukee Brewers | Boston Red Sox vs Milwaukee Brewers - Tue, May 27, 2025 | Away | American Family Field |
| Wed, May 28, 2025 | Milwaukee Brewers | Boston Red Sox vs Milwaukee Brewers - Wed, May 28, 2025 | Away | American Family Field |
| Fri, May 30, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Fri, May 30, 2025 | Away | Truist Park |
| Sat, May 31, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Sat, May 31, 2025 | Away | Truist Park |
| Sun, Jun 1, 2025 | Atlanta Braves | Boston Red Sox vs Atlanta Braves - Sun, Jun 1, 2025 | Away | Truist Park |
| Mon, Jun 2, 2025 | Los Angeles Angels | Boston Red Sox vs Los Angeles Angels - Mon, Jun 2, 2025 | Home | Fenway Park |
| Tue, Jun 3, 2025 | Los Angeles Angels | Boston Red Sox vs Los Angeles Angels - Tue, Jun 3, 2025 | Home | Fenway Park |
| Wed, Jun 4, 2025 | Los Angeles Angels | Boston Red Sox vs Los Angeles Angels - Wed, Jun 4, 2025 | Home | Fenway Park |
| Fri, Jun 6, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Fri, Jun 6, 2025 | Away | Yankee Stadium |
| Sat, Jun 7, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Sat, Jun 7, 2025 | Away | Yankee Stadium |
| Sun, Jun 8, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Sun, Jun 8, 2025 | Away | Yankee Stadium |
| Mon, Jun 9, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Mon, Jun 9, 2025 | Home | Fenway Park |
| Tue, Jun 10, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Tue, Jun 10, 2025 | Home | Fenway Park |
| Wed, Jun 11, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Wed, Jun 11, 2025 | Home | Fenway Park |
| Fri, Jun 13, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Fri, Jun 13, 2025 | Home | Fenway Park |
| Sat, Jun 14, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Sat, Jun 14, 2025 | Home | Fenway Park |
| Sun, Jun 15, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Sun, Jun 15, 2025 | Home | Fenway Park |
| Mon, Jun 16, 2025 | Seattle Mariners | Boston Red Sox vs Seattle Mariners - Mon, Jun 16, 2025 | Away | T-Mobile Park |
| Tue, Jun 17, 2025 | Seattle Mariners | Boston Red Sox vs Seattle Mariners - Tue, Jun 17, 2025 | Away | T-Mobile Park |
| Wed, Jun 18, 2025 | Seattle Mariners | Boston Red Sox vs Seattle Mariners - Wed, Jun 18, 2025 | Away | T-Mobile Park |
| Fri, Jun 20, 2025 | San Francisco Giants | Boston Red Sox vs San Francisco Giants - Fri, Jun 20, 2025 | Away | Oracle Park |
| Sat, Jun 21, 2025 | San Francisco Giants | Boston Red Sox vs San Francisco Giants - Sat, Jun 21, 2025 | Away | Oracle Park |
| Sun, Jun 22, 2025 | San Francisco Giants | Boston Red Sox vs San Francisco Giants - Sun, Jun 22, 2025 | Away | Oracle Park |
| Mon, Jun 23, 2025 | Los Angeles Angels | Boston Red Sox vs Los Angeles Angels - Mon, Jun 23, 2025 | Away | Angel Stadium |
| Tue, Jun 24, 2025 | Los Angeles Angels | Boston Red Sox vs Los Angeles Angels - Tue, Jun 24, 2025 | Away | Angel Stadium |
| Wed, Jun 25, 2025 | Los Angeles Angels | Boston Red Sox vs Los Angeles Angels - Wed, Jun 25, 2025 | Away | Angel Stadium |
| Fri, Jun 27, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Fri, Jun 27, 2025 | Home | Fenway Park |
| Sat, Jun 28, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Sat, Jun 28, 2025 | Home | Fenway Park |
| Sun, Jun 29, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Sun, Jun 29, 2025 | Home | Fenway Park |
| Mon, Jun 30, 2025 | Cincinnati Reds | Boston Red Sox vs Cincinnati Reds - Mon, Jun 30, 2025 | Home | Fenway Park |
| Tue, Jul 1, 2025 | Cincinnati Reds | Boston Red Sox vs Cincinnati Reds - Tue, Jul 1, 2025 | Home | Fenway Park |
| Wed, Jul 2, 2025 | Cincinnati Reds | Boston Red Sox vs Cincinnati Reds - Wed, Jul 2, 2025 | Home | Fenway Park |
| Fri, Jul 4, 2025 | Washington Nationals | Boston Red Sox vs Washington Nationals - Fri, Jul 4, 2025 | Away | Nationals Park |
| Sat, Jul 5, 2025 | Washington Nationals | Boston Red Sox vs Washington Nationals - Sat, Jul 5, 2025 | Away | Nationals Park |
| Sun, Jul 6, 2025 | Washington Nationals | Boston Red Sox vs Washington Nationals - Sun, Jul 6, 2025 | Away | Nationals Park |
| Mon, Jul 7, 2025 | Colorado Rockies | Boston Red Sox vs Colorado Rockies - Mon, Jul 7, 2025 | Home | Fenway Park |
| Tue, Jul 8, 2025 | Colorado Rockies | Boston Red Sox vs Colorado Rockies - Tue, Jul 8, 2025 | Home | Fenway Park |
| Wed, Jul 9, 2025 | Colorado Rockies | Boston Red Sox vs Colorado Rockies - Wed, Jul 9, 2025 | Home | Fenway Park |
| Thu, Jul 10, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Thu, Jul 10, 2025 | Home | Fenway Park |
| Fri, Jul 11, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Fri, Jul 11, 2025 | Home | Fenway Park |
| Sat, Jul 12, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Sat, Jul 12, 2025 | Home | Fenway Park |
| Sun, Jul 13, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Sun, Jul 13, 2025 | Home | Fenway Park |
| Fri, Jul 18, 2025 | Chicago Cubs | Boston Red Sox vs Chicago Cubs - Fri, Jul 18, 2025 | Away | Wrigley Field |
| Sat, Jul 19, 2025 | Chicago Cubs | Boston Red Sox vs Chicago Cubs - Sat, Jul 19, 2025 | Away | Wrigley Field |
| Sun, Jul 20, 2025 | Chicago Cubs | Boston Red Sox vs Chicago Cubs - Sun, Jul 20, 2025 | Away | Wrigley Field |
| Mon, Jul 21, 2025 | Philadelphia Phillies | Boston Red Sox vs Philadelphia Phillies - Mon, Jul 21, 2025 | Away | Citizens Bank Park |
| Tue, Jul 22, 2025 | Philadelphia Phillies | Boston Red Sox vs Philadelphia Phillies - Tue, Jul 22, 2025 | Away | Citizens Bank Park |
| Wed, Jul 23, 2025 | Philadelphia Phillies | Boston Red Sox vs Philadelphia Phillies - Wed, Jul 23, 2025 | Away | Citizens Bank Park |
| Fri, Jul 25, 2025 | Los Angeles Dodgers | Boston Red Sox vs Los Angeles Dodgers - Fri, Jul 25, 2025 | Home | Fenway Park |
| Sat, Jul 26, 2025 | Los Angeles Dodgers | Boston Red Sox vs Los Angeles Dodgers - Sat, Jul 26, 2025 | Home | Fenway Park |
| Sun, Jul 27, 2025 | Los Angeles Dodgers | Boston Red Sox vs Los Angeles Dodgers - Sun, Jul 27, 2025 | Home | Fenway Park |
| Mon, Jul 28, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Mon, Jul 28, 2025 | Away | Target Field |
| Tue, Jul 29, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Tue, Jul 29, 2025 | Away | Target Field |
| Wed, Jul 30, 2025 | Minnesota Twins | Boston Red Sox vs Minnesota Twins - Wed, Jul 30, 2025 | Away | Target Field |
| Fri, Aug 1, 2025 | Houston Astros | Boston Red Sox vs Houston Astros - Fri, Aug 1, 2025 | Home | Fenway Park |
| Sat, Aug 2, 2025 | Houston Astros | Boston Red Sox vs Houston Astros - Sat, Aug 2, 2025 | Home | Fenway Park |
| Sun, Aug 3, 2025 | Houston Astros | Boston Red Sox vs Houston Astros - Sun, Aug 3, 2025 | Home | Fenway Park |
| Mon, Aug 4, 2025 | Kansas City Royals | Boston Red Sox vs Kansas City Royals - Mon, Aug 4, 2025 | Home | Fenway Park |
| Tue, Aug 5, 2025 | Kansas City Royals | Boston Red Sox vs Kansas City Royals - Tue, Aug 5, 2025 | Home | Fenway Park |
| Wed, Aug 6, 2025 | Kansas City Royals | Boston Red Sox vs Kansas City Royals - Wed, Aug 6, 2025 | Home | Fenway Park |
| Fri, Aug 8, 2025 | San Diego Padres | Boston Red Sox vs San Diego Padres - Fri, Aug 8, 2025 | Away | Petco Park |
| Sat, Aug 9, 2025 | San Diego Padres | Boston Red Sox vs San Diego Padres - Sat, Aug 9, 2025 | Away | Petco Park |
| Sun, Aug 10, 2025 | San Diego Padres | Boston Red Sox vs San Diego Padres - Sun, Aug 10, 2025 | Away | Petco Park |
| Mon, Aug 11, 2025 | Houston Astros | Boston Red Sox vs Houston Astros - Mon, Aug 11, 2025 | Away | Daikin Park |
| Tue, Aug 12, 2025 | Houston Astros | Boston Red Sox vs Houston Astros - Tue, Aug 12, 2025 | Away | Daikin Park |
| Wed, Aug 13, 2025 | Houston Astros | Boston Red Sox vs Houston Astros - Wed, Aug 13, 2025 | Away | Daikin Park |
| Fri, Aug 15, 2025 | Miami Marlins | Boston Red Sox vs Miami Marlins - Fri, Aug 15, 2025 | Home | Fenway Park |
| Sat, Aug 16, 2025 | Miami Marlins | Boston Red Sox vs Miami Marlins - Sat, Aug 16, 2025 | Home | Fenway Park |
| Sun, Aug 17, 2025 | Miami Marlins | Boston Red Sox vs Miami Marlins - Sun, Aug 17, 2025 | Home | Fenway Park |
| Mon, Aug 18, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Mon, Aug 18, 2025 | Home | Fenway Park |
| Tue, Aug 19, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Tue, Aug 19, 2025 | Home | Fenway Park |
| Thu, Aug 21, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Thu, Aug 21, 2025 | Away | Yankee Stadium |
| Fri, Aug 22, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Fri, Aug 22, 2025 | Away | Yankee Stadium |
| Sat, Aug 23, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Sat, Aug 23, 2025 | Away | Yankee Stadium |
| Sun, Aug 24, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Sun, Aug 24, 2025 | Away | Yankee Stadium |
| Mon, Aug 25, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Mon, Aug 25, 2025 | Away | Oriole Park at Camden Yards |
| Tue, Aug 26, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Tue, Aug 26, 2025 | Away | Oriole Park at Camden Yards |
| Wed, Aug 27, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Wed, Aug 27, 2025 | Away | Oriole Park at Camden Yards |
| Thu, Aug 28, 2025 | Baltimore Orioles | Boston Red Sox vs Baltimore Orioles - Thu, Aug 28, 2025 | Away | Oriole Park at Camden Yards |
| Fri, Aug 29, 2025 | Pittsburgh Pirates | Boston Red Sox vs Pittsburgh Pirates - Fri, Aug 29, 2025 | Home | Fenway Park |
| Sat, Aug 30, 2025 | Pittsburgh Pirates | Boston Red Sox vs Pittsburgh Pirates - Sat, Aug 30, 2025 | Home | Fenway Park |
| Sun, Aug 31, 2025 | Pittsburgh Pirates | Boston Red Sox vs Pittsburgh Pirates - Sun, Aug 31, 2025 | Home | Fenway Park |
| Mon, Sep 1, 2025 | Cleveland Guardians | Boston Red Sox vs Cleveland Guardians - Mon, Sep 1, 2025 | Home | Fenway Park |
| Tue, Sep 2, 2025 | Cleveland Guardians | Boston Red Sox vs Cleveland Guardians - Tue, Sep 2, 2025 | Home | Fenway Park |
| Wed, Sep 3, 2025 | Cleveland Guardians | Boston Red Sox vs Cleveland Guardians - Wed, Sep 3, 2025 | Home | Fenway Park |
| Fri, Sep 5, 2025 | Arizona Diamondbacks | Boston Red Sox vs Arizona Diamondbacks - Fri, Sep 5, 2025 | Away | Chase Field |
| Sat, Sep 6, 2025 | Arizona Diamondbacks | Boston Red Sox vs Arizona Diamondbacks - Sat, Sep 6, 2025 | Away | Chase Field |
| Sun, Sep 7, 2025 | Arizona Diamondbacks | Boston Red Sox vs Arizona Diamondbacks - Sun, Sep 7, 2025 | Away | Chase Field |
| Mon, Sep 8, 2025 | Oakland Athletics | Boston Red Sox vs Oakland Athletics - Mon, Sep 8, 2025 | Away | Sutter Health Park |
| Tue, Sep 9, 2025 | Oakland Athletics | Boston Red Sox vs Oakland Athletics - Tue, Sep 9, 2025 | Away | Sutter Health Park |
| Wed, Sep 10, 2025 | Oakland Athletics | Boston Red Sox vs Oakland Athletics - Wed, Sep 10, 2025 | Away | Sutter Health Park |
| Fri, Sep 12, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Fri, Sep 12, 2025 | Home | Fenway Park |
| Sat, Sep 13, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Sat, Sep 13, 2025 | Home | Fenway Park |
| Sun, Sep 14, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Sun, Sep 14, 2025 | Home | Fenway Park |
| Tue, Sep 16, 2025 | Oakland Athletics | Boston Red Sox vs Oakland Athletics - Tue, Sep 16, 2025 | Home | Fenway Park |
| Wed, Sep 17, 2025 | Oakland Athletics | Boston Red Sox vs Oakland Athletics - Wed, Sep 17, 2025 | Home | Fenway Park |
| Thu, Sep 18, 2025 | Oakland Athletics | Boston Red Sox vs Oakland Athletics - Thu, Sep 18, 2025 | Home | Fenway Park |
| Fri, Sep 19, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Fri, Sep 19, 2025 | Away | George M. Steinbrenner Field |
| Sat, Sep 20, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Sat, Sep 20, 2025 | Away | George M. Steinbrenner Field |
| Sun, Sep 21, 2025 | Tampa Bay Rays | Boston Red Sox vs Tampa Bay Rays - Sun, Sep 21, 2025 | Away | George M. Steinbrenner Field |
| Tue, Sep 23, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Tue, Sep 23, 2025 | Away | Rogers Centre |
| Wed, Sep 24, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Wed, Sep 24, 2025 | Away | Rogers Centre |
| Thu, Sep 25, 2025 | Toronto Blue Jays | Boston Red Sox vs Toronto Blue Jays - Thu, Sep 25, 2025 | Away | Rogers Centre |
| Fri, Sep 26, 2025 | Detroit Tigers | Boston Red Sox vs Detroit Tigers - Fri, Sep 26, 2025 | Home | Fenway Park |
| Sat, Sep 27, 2025 | Detroit Tigers | Boston Red Sox vs Detroit Tigers - Sat, Sep 27, 2025 | Home | Fenway Park |
| Sun, Sep 28, 2025 | Detroit Tigers | Boston Red Sox vs Detroit Tigers - Sun, Sep 28, 2025 | Home | Fenway Park |
| Tue, Sep 30, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Tue, Sep 30, 2025 | Away | Yankee Stadium |
| Wed, Oct 1, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Wed, Oct 1, 2025 | Away | Yankee Stadium |
| Thu, Oct 2, 2025 | New York Yankees | Boston Red Sox vs New York Yankees - Thu, Oct 2, 2025 | Away | Yankee Stadium |
