| Sat, Feb 22, 2025 | Cincinnati Reds | Cleveland Guardians vs Cincinnati Reds - Sat, Feb 22, 2025 | Away | Goodyear Ballpark |
| Sun, Feb 23, 2025 | Los Angeles Angels | Cleveland Guardians vs Los Angeles Angels - Sun, Feb 23, 2025 | Home | Goodyear Ballpark |
| Mon, Feb 24, 2025 | Arizona Diamondbacks | Cleveland Guardians vs Arizona Diamondbacks - Mon, Feb 24, 2025 | Away | Salt River Fields at Talking Stick |
| Tue, Feb 25, 2025 | Milwaukee Brewers | Cleveland Guardians vs Milwaukee Brewers - Tue, Feb 25, 2025 | Home | Goodyear Ballpark |
| Wed, Feb 26, 2025 | Texas Rangers | Cleveland Guardians vs Texas Rangers - Wed, Feb 26, 2025 | Home | Goodyear Ballpark |
| Thu, Feb 27, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Thu, Feb 27, 2025 | Away | Camelback Ranch |
| Fri, Feb 28, 2025 | Colorado Rockies | Cleveland Guardians vs Colorado Rockies - Fri, Feb 28, 2025 | Home | Goodyear Ballpark |
| Sat, Mar 1, 2025 | Chicago Cubs | Cleveland Guardians vs Chicago Cubs - Sat, Mar 1, 2025 | Away | Sloan Park |
| Sun, Mar 2, 2025 | Milwaukee Brewers | Cleveland Guardians vs Milwaukee Brewers - Sun, Mar 2, 2025 | Home | Goodyear Ballpark |
| Mon, Mar 3, 2025 | Seattle Mariners | Cleveland Guardians vs Seattle Mariners - Mon, Mar 3, 2025 | Away | Peoria Stadium |
| Tue, Mar 4, 2025 | Los Angeles Angels | Cleveland Guardians vs Los Angeles Angels - Tue, Mar 4, 2025 | Home | Goodyear Ballpark |
| Thu, Mar 6, 2025 | Arizona Diamondbacks | Cleveland Guardians vs Arizona Diamondbacks - Thu, Mar 6, 2025 | Home | Goodyear Ballpark |
| Fri, Mar 7, 2025 | Oakland Athletics | Cleveland Guardians vs Oakland Athletics - Fri, Mar 7, 2025 | Away | Hohokam Stadium |
| Sat, Mar 8, 2025 | San Diego Padres | Cleveland Guardians vs San Diego Padres - Sat, Mar 8, 2025 | Away | Peoria Stadium |
| Sun, Mar 9, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Sun, Mar 9, 2025 | Home | Goodyear Ballpark |
| Mon, Mar 10, 2025 | Chicago Cubs | Cleveland Guardians vs Chicago Cubs - Mon, Mar 10, 2025 | Home | Goodyear Ballpark |
| Mon, Mar 10, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Mon, Mar 10, 2025 | Away | Surprise Stadium |
| Tue, Mar 11, 2025 | Los Angeles Dodgers | Cleveland Guardians vs Los Angeles Dodgers - Tue, Mar 11, 2025 | Away | Camelback Ranch |
| Wed, Mar 12, 2025 | San Francisco Giants | Cleveland Guardians vs San Francisco Giants - Wed, Mar 12, 2025 | Home | Goodyear Ballpark |
| Thu, Mar 13, 2025 | Colorado Rockies | Cleveland Guardians vs Colorado Rockies - Thu, Mar 13, 2025 | Away | Salt River Fields at Talking Stick |
| Fri, Mar 14, 2025 | Seattle Mariners | Cleveland Guardians vs Seattle Mariners - Fri, Mar 14, 2025 | Home | Goodyear Ballpark |
| Sat, Mar 15, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Sat, Mar 15, 2025 | Away | Surprise Stadium |
| Sun, Mar 16, 2025 | Milwaukee Brewers | Cleveland Guardians vs Milwaukee Brewers - Sun, Mar 16, 2025 | Away | American Family Fields of Phoenix |
| Mon, Mar 17, 2025 | Cincinnati Reds | Cleveland Guardians vs Cincinnati Reds - Mon, Mar 17, 2025 | Home | Goodyear Ballpark |
| Tue, Mar 18, 2025 | Texas Rangers | Cleveland Guardians vs Texas Rangers - Tue, Mar 18, 2025 | Away | Surprise Stadium |
| Wed, Mar 19, 2025 | Oakland Athletics | Cleveland Guardians vs Oakland Athletics - Wed, Mar 19, 2025 | Home | Goodyear Ballpark |
| Wed, Mar 19, 2025 | Los Angeles Angels | Cleveland Guardians vs Los Angeles Angels - Wed, Mar 19, 2025 | Away | Tempe Diablo Stadium |
| Fri, Mar 21, 2025 | San Francisco Giants | Cleveland Guardians vs San Francisco Giants - Fri, Mar 21, 2025 | Away | Scottsdale Stadium |
| Sat, Mar 22, 2025 | San Diego Padres | Cleveland Guardians vs San Diego Padres - Sat, Mar 22, 2025 | Home | Goodyear Ballpark |
| Sun, Mar 23, 2025 | Cincinnati Reds | Cleveland Guardians vs Cincinnati Reds - Sun, Mar 23, 2025 | Away | Goodyear Ballpark |
| Mon, Mar 24, 2025 | Arizona Diamondbacks | Cleveland Guardians vs Arizona Diamondbacks - Mon, Mar 24, 2025 | Away | Chase Field |
| Tue, Mar 25, 2025 | Arizona Diamondbacks | Cleveland Guardians vs Arizona Diamondbacks - Tue, Mar 25, 2025 | Away | Chase Field |
| Thu, Mar 27, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Thu, Mar 27, 2025 | Away | Kauffman Stadium |
| Sat, Mar 29, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Sat, Mar 29, 2025 | Away | Kauffman Stadium |
| Sun, Mar 30, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Sun, Mar 30, 2025 | Away | Kauffman Stadium |
| Mon, Mar 31, 2025 | San Diego Padres | Cleveland Guardians vs San Diego Padres - Mon, Mar 31, 2025 | Away | Petco Park |
| Tue, Apr 1, 2025 | San Diego Padres | Cleveland Guardians vs San Diego Padres - Tue, Apr 1, 2025 | Away | Petco Park |
| Wed, Apr 2, 2025 | San Diego Padres | Cleveland Guardians vs San Diego Padres - Wed, Apr 2, 2025 | Away | Petco Park |
| Fri, Apr 4, 2025 | Los Angeles Angels | Cleveland Guardians vs Los Angeles Angels - Fri, Apr 4, 2025 | Away | Angel Stadium |
| Sat, Apr 5, 2025 | Los Angeles Angels | Cleveland Guardians vs Los Angeles Angels - Sat, Apr 5, 2025 | Away | Angel Stadium |
| Sun, Apr 6, 2025 | Los Angeles Angels | Cleveland Guardians vs Los Angeles Angels - Sun, Apr 6, 2025 | Away | Angel Stadium |
| Tue, Apr 8, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Tue, Apr 8, 2025 | Home | Progressive Field |
| Wed, Apr 9, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Wed, Apr 9, 2025 | Home | Progressive Field |
| Thu, Apr 10, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Thu, Apr 10, 2025 | Home | Progressive Field |
| Fri, Apr 11, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Fri, Apr 11, 2025 | Home | Progressive Field |
| Sat, Apr 12, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Sat, Apr 12, 2025 | Home | Progressive Field |
| Sun, Apr 13, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Sun, Apr 13, 2025 | Home | Progressive Field |
| Tue, Apr 15, 2025 | Baltimore Orioles | Cleveland Guardians vs Baltimore Orioles - Tue, Apr 15, 2025 | Away | Oriole Park at Camden Yards |
| Wed, Apr 16, 2025 | Baltimore Orioles | Cleveland Guardians vs Baltimore Orioles - Wed, Apr 16, 2025 | Away | Oriole Park at Camden Yards |
| Thu, Apr 17, 2025 | Baltimore Orioles | Cleveland Guardians vs Baltimore Orioles - Thu, Apr 17, 2025 | Away | Oriole Park at Camden Yards |
| Fri, Apr 18, 2025 | Pittsburgh Pirates | Cleveland Guardians vs Pittsburgh Pirates - Fri, Apr 18, 2025 | Away | PNC Park |
| Sat, Apr 19, 2025 | Pittsburgh Pirates | Cleveland Guardians vs Pittsburgh Pirates - Sat, Apr 19, 2025 | Away | PNC Park |
| Sun, Apr 20, 2025 | Pittsburgh Pirates | Cleveland Guardians vs Pittsburgh Pirates - Sun, Apr 20, 2025 | Away | PNC Park |
| Mon, Apr 21, 2025 | New York Yankees | Cleveland Guardians vs New York Yankees - Mon, Apr 21, 2025 | Home | Progressive Field |
| Tue, Apr 22, 2025 | New York Yankees | Cleveland Guardians vs New York Yankees - Tue, Apr 22, 2025 | Home | Progressive Field |
| Wed, Apr 23, 2025 | New York Yankees | Cleveland Guardians vs New York Yankees - Wed, Apr 23, 2025 | Home | Progressive Field |
| Sat, Apr 26, 2025 | Boston Red Sox | Cleveland Guardians vs Boston Red Sox - Sat, Apr 26, 2025 | Home | Progressive Field |
| Sat, Apr 26, 2025 | Boston Red Sox | Cleveland Guardians vs Boston Red Sox - Sat, Apr 26, 2025 | Home | Progressive Field |
| Sun, Apr 27, 2025 | Boston Red Sox | Cleveland Guardians vs Boston Red Sox - Sun, Apr 27, 2025 | Home | Progressive Field |
| Mon, Apr 28, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Mon, Apr 28, 2025 | Home | Progressive Field |
| Tue, Apr 29, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Tue, Apr 29, 2025 | Home | Progressive Field |
| Wed, Apr 30, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Wed, Apr 30, 2025 | Home | Progressive Field |
| Thu, May 1, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Thu, May 1, 2025 | Home | Progressive Field |
| Fri, May 2, 2025 | Toronto Blue Jays | Cleveland Guardians vs Toronto Blue Jays - Fri, May 2, 2025 | Away | Rogers Centre |
| Sat, May 3, 2025 | Toronto Blue Jays | Cleveland Guardians vs Toronto Blue Jays - Sat, May 3, 2025 | Away | Rogers Centre |
| Sun, May 4, 2025 | Toronto Blue Jays | Cleveland Guardians vs Toronto Blue Jays - Sun, May 4, 2025 | Away | Rogers Centre |
| Tue, May 6, 2025 | Washington Nationals | Cleveland Guardians vs Washington Nationals - Tue, May 6, 2025 | Away | Nationals Park |
| Tue, May 6, 2025 | Washington Nationals | Cleveland Guardians vs Washington Nationals - Tue, May 6, 2025 | Away | Nationals Park |
| Wed, May 7, 2025 | Washington Nationals | Cleveland Guardians vs Washington Nationals - Wed, May 7, 2025 | Away | Nationals Park |
| Fri, May 9, 2025 | Philadelphia Phillies | Cleveland Guardians vs Philadelphia Phillies - Fri, May 9, 2025 | Home | Progressive Field |
| Sat, May 10, 2025 | Philadelphia Phillies | Cleveland Guardians vs Philadelphia Phillies - Sat, May 10, 2025 | Home | Progressive Field |
| Sun, May 11, 2025 | Philadelphia Phillies | Cleveland Guardians vs Philadelphia Phillies - Sun, May 11, 2025 | Home | Progressive Field |
| Mon, May 12, 2025 | Milwaukee Brewers | Cleveland Guardians vs Milwaukee Brewers - Mon, May 12, 2025 | Home | Progressive Field |
| Tue, May 13, 2025 | Milwaukee Brewers | Cleveland Guardians vs Milwaukee Brewers - Tue, May 13, 2025 | Home | Progressive Field |
| Wed, May 14, 2025 | Milwaukee Brewers | Cleveland Guardians vs Milwaukee Brewers - Wed, May 14, 2025 | Home | Progressive Field |
| Fri, May 16, 2025 | Cincinnati Reds | Cleveland Guardians vs Cincinnati Reds - Fri, May 16, 2025 | Away | Great American Ball Park |
| Sat, May 17, 2025 | Cincinnati Reds | Cleveland Guardians vs Cincinnati Reds - Sat, May 17, 2025 | Away | Great American Ball Park |
| Sun, May 18, 2025 | Cincinnati Reds | Cleveland Guardians vs Cincinnati Reds - Sun, May 18, 2025 | Away | Great American Ball Park |
| Mon, May 19, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Mon, May 19, 2025 | Away | Target Field |
| Wed, May 21, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Wed, May 21, 2025 | Away | Target Field |
| Thu, May 22, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Thu, May 22, 2025 | Away | Comerica Park |
| Fri, May 23, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Fri, May 23, 2025 | Away | Comerica Park |
| Sat, May 24, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Sat, May 24, 2025 | Away | Comerica Park |
| Sun, May 25, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Sun, May 25, 2025 | Away | Comerica Park |
| Mon, May 26, 2025 | Los Angeles Dodgers | Cleveland Guardians vs Los Angeles Dodgers - Mon, May 26, 2025 | Home | Progressive Field |
| Tue, May 27, 2025 | Los Angeles Dodgers | Cleveland Guardians vs Los Angeles Dodgers - Tue, May 27, 2025 | Home | Progressive Field |
| Wed, May 28, 2025 | Los Angeles Dodgers | Cleveland Guardians vs Los Angeles Dodgers - Wed, May 28, 2025 | Home | Progressive Field |
| Fri, May 30, 2025 | Los Angeles Angels | Cleveland Guardians vs Los Angeles Angels - Fri, May 30, 2025 | Home | Progressive Field |
| Sat, May 31, 2025 | Los Angeles Angels | Cleveland Guardians vs Los Angeles Angels - Sat, May 31, 2025 | Home | Progressive Field |
| Sun, Jun 1, 2025 | Los Angeles Angels | Cleveland Guardians vs Los Angeles Angels - Sun, Jun 1, 2025 | Home | Progressive Field |
| Tue, Jun 3, 2025 | New York Yankees | Cleveland Guardians vs New York Yankees - Tue, Jun 3, 2025 | Away | Yankee Stadium |
| Wed, Jun 4, 2025 | New York Yankees | Cleveland Guardians vs New York Yankees - Wed, Jun 4, 2025 | Away | Yankee Stadium |
| Thu, Jun 5, 2025 | New York Yankees | Cleveland Guardians vs New York Yankees - Thu, Jun 5, 2025 | Away | Yankee Stadium |
| Fri, Jun 6, 2025 | Houston Astros | Cleveland Guardians vs Houston Astros - Fri, Jun 6, 2025 | Home | Progressive Field |
| Sat, Jun 7, 2025 | Houston Astros | Cleveland Guardians vs Houston Astros - Sat, Jun 7, 2025 | Home | Progressive Field |
| Sun, Jun 8, 2025 | Houston Astros | Cleveland Guardians vs Houston Astros - Sun, Jun 8, 2025 | Home | Progressive Field |
| Mon, Jun 9, 2025 | Cincinnati Reds | Cleveland Guardians vs Cincinnati Reds - Mon, Jun 9, 2025 | Home | Progressive Field |
| Tue, Jun 10, 2025 | Cincinnati Reds | Cleveland Guardians vs Cincinnati Reds - Tue, Jun 10, 2025 | Home | Progressive Field |
| Wed, Jun 11, 2025 | Cincinnati Reds | Cleveland Guardians vs Cincinnati Reds - Wed, Jun 11, 2025 | Home | Progressive Field |
| Fri, Jun 13, 2025 | Seattle Mariners | Cleveland Guardians vs Seattle Mariners - Fri, Jun 13, 2025 | Away | T-Mobile Park |
| Sat, Jun 14, 2025 | Seattle Mariners | Cleveland Guardians vs Seattle Mariners - Sat, Jun 14, 2025 | Away | T-Mobile Park |
| Sun, Jun 15, 2025 | Seattle Mariners | Cleveland Guardians vs Seattle Mariners - Sun, Jun 15, 2025 | Away | T-Mobile Park |
| Tue, Jun 17, 2025 | San Francisco Giants | Cleveland Guardians vs San Francisco Giants - Tue, Jun 17, 2025 | Away | Oracle Park |
| Wed, Jun 18, 2025 | San Francisco Giants | Cleveland Guardians vs San Francisco Giants - Wed, Jun 18, 2025 | Away | Oracle Park |
| Thu, Jun 19, 2025 | San Francisco Giants | Cleveland Guardians vs San Francisco Giants - Thu, Jun 19, 2025 | Away | Oracle Park |
| Fri, Jun 20, 2025 | Oakland Athletics | Cleveland Guardians vs Oakland Athletics - Fri, Jun 20, 2025 | Away | Sutter Health Park |
| Sat, Jun 21, 2025 | Oakland Athletics | Cleveland Guardians vs Oakland Athletics - Sat, Jun 21, 2025 | Away | Sutter Health Park |
| Sun, Jun 22, 2025 | Oakland Athletics | Cleveland Guardians vs Oakland Athletics - Sun, Jun 22, 2025 | Away | Sutter Health Park |
| Tue, Jun 24, 2025 | Toronto Blue Jays | Cleveland Guardians vs Toronto Blue Jays - Tue, Jun 24, 2025 | Home | Progressive Field |
| Wed, Jun 25, 2025 | Toronto Blue Jays | Cleveland Guardians vs Toronto Blue Jays - Wed, Jun 25, 2025 | Home | Progressive Field |
| Thu, Jun 26, 2025 | Toronto Blue Jays | Cleveland Guardians vs Toronto Blue Jays - Thu, Jun 26, 2025 | Home | Progressive Field |
| Fri, Jun 27, 2025 | St Louis Cardinals | Cleveland Guardians vs St Louis Cardinals - Fri, Jun 27, 2025 | Home | Progressive Field |
| Sat, Jun 28, 2025 | St Louis Cardinals | Cleveland Guardians vs St Louis Cardinals - Sat, Jun 28, 2025 | Home | Progressive Field |
| Sun, Jun 29, 2025 | St Louis Cardinals | Cleveland Guardians vs St Louis Cardinals - Sun, Jun 29, 2025 | Home | Progressive Field |
| Tue, Jul 1, 2025 | Chicago Cubs | Cleveland Guardians vs Chicago Cubs - Tue, Jul 1, 2025 | Away | Wrigley Field |
| Wed, Jul 2, 2025 | Chicago Cubs | Cleveland Guardians vs Chicago Cubs - Wed, Jul 2, 2025 | Away | Wrigley Field |
| Thu, Jul 3, 2025 | Chicago Cubs | Cleveland Guardians vs Chicago Cubs - Thu, Jul 3, 2025 | Away | Wrigley Field |
| Fri, Jul 4, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Fri, Jul 4, 2025 | Home | Progressive Field |
| Sat, Jul 5, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Sat, Jul 5, 2025 | Home | Progressive Field |
| Sun, Jul 6, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Sun, Jul 6, 2025 | Home | Progressive Field |
| Mon, Jul 7, 2025 | Houston Astros | Cleveland Guardians vs Houston Astros - Mon, Jul 7, 2025 | Away | Daikin Park |
| Tue, Jul 8, 2025 | Houston Astros | Cleveland Guardians vs Houston Astros - Tue, Jul 8, 2025 | Away | Daikin Park |
| Wed, Jul 9, 2025 | Houston Astros | Cleveland Guardians vs Houston Astros - Wed, Jul 9, 2025 | Away | Daikin Park |
| Fri, Jul 11, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Fri, Jul 11, 2025 | Away | Rate Field |
| Fri, Jul 11, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Fri, Jul 11, 2025 | Away | Rate Field |
| Sat, Jul 12, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Sat, Jul 12, 2025 | Away | Rate Field |
| Sun, Jul 13, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Sun, Jul 13, 2025 | Away | Rate Field |
| Fri, Jul 18, 2025 | Oakland Athletics | Cleveland Guardians vs Oakland Athletics - Fri, Jul 18, 2025 | Home | Progressive Field |
| Sat, Jul 19, 2025 | Oakland Athletics | Cleveland Guardians vs Oakland Athletics - Sat, Jul 19, 2025 | Home | Progressive Field |
| Sun, Jul 20, 2025 | Oakland Athletics | Cleveland Guardians vs Oakland Athletics - Sun, Jul 20, 2025 | Home | Progressive Field |
| Mon, Jul 21, 2025 | Baltimore Orioles | Cleveland Guardians vs Baltimore Orioles - Mon, Jul 21, 2025 | Home | Progressive Field |
| Tue, Jul 22, 2025 | Baltimore Orioles | Cleveland Guardians vs Baltimore Orioles - Tue, Jul 22, 2025 | Home | Progressive Field |
| Wed, Jul 23, 2025 | Baltimore Orioles | Cleveland Guardians vs Baltimore Orioles - Wed, Jul 23, 2025 | Home | Progressive Field |
| Thu, Jul 24, 2025 | Baltimore Orioles | Cleveland Guardians vs Baltimore Orioles - Thu, Jul 24, 2025 | Home | Progressive Field |
| Sat, Jul 26, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Sat, Jul 26, 2025 | Away | Kauffman Stadium |
| Sat, Jul 26, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Sat, Jul 26, 2025 | Away | Kauffman Stadium |
| Sun, Jul 27, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Sun, Jul 27, 2025 | Away | Kauffman Stadium |
| Mon, Jul 28, 2025 | Colorado Rockies | Cleveland Guardians vs Colorado Rockies - Mon, Jul 28, 2025 | Home | Progressive Field |
| Tue, Jul 29, 2025 | Colorado Rockies | Cleveland Guardians vs Colorado Rockies - Tue, Jul 29, 2025 | Home | Progressive Field |
| Wed, Jul 30, 2025 | Colorado Rockies | Cleveland Guardians vs Colorado Rockies - Wed, Jul 30, 2025 | Home | Progressive Field |
| Fri, Aug 1, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Fri, Aug 1, 2025 | Home | Progressive Field |
| Sat, Aug 2, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Sat, Aug 2, 2025 | Home | Progressive Field |
| Sun, Aug 3, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Sun, Aug 3, 2025 | Home | Progressive Field |
| Mon, Aug 4, 2025 | New York Mets | Cleveland Guardians vs New York Mets - Mon, Aug 4, 2025 | Away | Citi Field |
| Tue, Aug 5, 2025 | New York Mets | Cleveland Guardians vs New York Mets - Tue, Aug 5, 2025 | Away | Citi Field |
| Wed, Aug 6, 2025 | New York Mets | Cleveland Guardians vs New York Mets - Wed, Aug 6, 2025 | Away | Citi Field |
| Fri, Aug 8, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Fri, Aug 8, 2025 | Away | Rate Field |
| Sat, Aug 9, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Sat, Aug 9, 2025 | Away | Rate Field |
| Sun, Aug 10, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Sun, Aug 10, 2025 | Away | Rate Field |
| Tue, Aug 12, 2025 | Miami Marlins | Cleveland Guardians vs Miami Marlins - Tue, Aug 12, 2025 | Home | Progressive Field |
| Wed, Aug 13, 2025 | Miami Marlins | Cleveland Guardians vs Miami Marlins - Wed, Aug 13, 2025 | Home | Progressive Field |
| Thu, Aug 14, 2025 | Miami Marlins | Cleveland Guardians vs Miami Marlins - Thu, Aug 14, 2025 | Home | Progressive Field |
| Fri, Aug 15, 2025 | Atlanta Braves | Cleveland Guardians vs Atlanta Braves - Fri, Aug 15, 2025 | Home | Progressive Field |
| Sat, Aug 16, 2025 | Atlanta Braves | Cleveland Guardians vs Atlanta Braves - Sat, Aug 16, 2025 | Home | Progressive Field |
| Sun, Aug 17, 2025 | Atlanta Braves | Cleveland Guardians vs Atlanta Braves - Sun, Aug 17, 2025 | Home | Progressive Field |
| Mon, Aug 18, 2025 | Arizona Diamondbacks | Cleveland Guardians vs Arizona Diamondbacks - Mon, Aug 18, 2025 | Away | Chase Field |
| Tue, Aug 19, 2025 | Arizona Diamondbacks | Cleveland Guardians vs Arizona Diamondbacks - Tue, Aug 19, 2025 | Away | Chase Field |
| Wed, Aug 20, 2025 | Arizona Diamondbacks | Cleveland Guardians vs Arizona Diamondbacks - Wed, Aug 20, 2025 | Away | Chase Field |
| Fri, Aug 22, 2025 | Texas Rangers | Cleveland Guardians vs Texas Rangers - Fri, Aug 22, 2025 | Away | Globe Life Field |
| Sat, Aug 23, 2025 | Texas Rangers | Cleveland Guardians vs Texas Rangers - Sat, Aug 23, 2025 | Away | Globe Life Field |
| Sun, Aug 24, 2025 | Texas Rangers | Cleveland Guardians vs Texas Rangers - Sun, Aug 24, 2025 | Away | Globe Life Field |
| Mon, Aug 25, 2025 | Tampa Bay Rays | Cleveland Guardians vs Tampa Bay Rays - Mon, Aug 25, 2025 | Home | Progressive Field |
| Tue, Aug 26, 2025 | Tampa Bay Rays | Cleveland Guardians vs Tampa Bay Rays - Tue, Aug 26, 2025 | Home | Progressive Field |
| Wed, Aug 27, 2025 | Tampa Bay Rays | Cleveland Guardians vs Tampa Bay Rays - Wed, Aug 27, 2025 | Home | Progressive Field |
| Fri, Aug 29, 2025 | Seattle Mariners | Cleveland Guardians vs Seattle Mariners - Fri, Aug 29, 2025 | Home | Progressive Field |
| Sat, Aug 30, 2025 | Seattle Mariners | Cleveland Guardians vs Seattle Mariners - Sat, Aug 30, 2025 | Home | Progressive Field |
| Sun, Aug 31, 2025 | Seattle Mariners | Cleveland Guardians vs Seattle Mariners - Sun, Aug 31, 2025 | Home | Progressive Field |
| Mon, Sep 1, 2025 | Boston Red Sox | Cleveland Guardians vs Boston Red Sox - Mon, Sep 1, 2025 | Away | Fenway Park |
| Tue, Sep 2, 2025 | Boston Red Sox | Cleveland Guardians vs Boston Red Sox - Tue, Sep 2, 2025 | Away | Fenway Park |
| Wed, Sep 3, 2025 | Boston Red Sox | Cleveland Guardians vs Boston Red Sox - Wed, Sep 3, 2025 | Away | Fenway Park |
| Thu, Sep 4, 2025 | Tampa Bay Rays | Cleveland Guardians vs Tampa Bay Rays - Thu, Sep 4, 2025 | Away | George M. Steinbrenner Field |
| Fri, Sep 5, 2025 | Tampa Bay Rays | Cleveland Guardians vs Tampa Bay Rays - Fri, Sep 5, 2025 | Away | George M. Steinbrenner Field |
| Sat, Sep 6, 2025 | Tampa Bay Rays | Cleveland Guardians vs Tampa Bay Rays - Sat, Sep 6, 2025 | Away | George M. Steinbrenner Field |
| Sun, Sep 7, 2025 | Tampa Bay Rays | Cleveland Guardians vs Tampa Bay Rays - Sun, Sep 7, 2025 | Away | George M. Steinbrenner Field |
| Mon, Sep 8, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Mon, Sep 8, 2025 | Home | Progressive Field |
| Tue, Sep 9, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Tue, Sep 9, 2025 | Home | Progressive Field |
| Wed, Sep 10, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Wed, Sep 10, 2025 | Home | Progressive Field |
| Thu, Sep 11, 2025 | Kansas City Royals | Cleveland Guardians vs Kansas City Royals - Thu, Sep 11, 2025 | Home | Progressive Field |
| Fri, Sep 12, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Fri, Sep 12, 2025 | Home | Progressive Field |
| Sat, Sep 13, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Sat, Sep 13, 2025 | Home | Progressive Field |
| Sun, Sep 14, 2025 | Chicago White Sox | Cleveland Guardians vs Chicago White Sox - Sun, Sep 14, 2025 | Home | Progressive Field |
| Tue, Sep 16, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Tue, Sep 16, 2025 | Away | Comerica Park |
| Wed, Sep 17, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Wed, Sep 17, 2025 | Away | Comerica Park |
| Thu, Sep 18, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Thu, Sep 18, 2025 | Away | Comerica Park |
| Fri, Sep 19, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Fri, Sep 19, 2025 | Away | Target Field |
| Sat, Sep 20, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Sat, Sep 20, 2025 | Away | Target Field |
| Sat, Sep 20, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Sat, Sep 20, 2025 | Away | Target Field |
| Sun, Sep 21, 2025 | Minnesota Twins | Cleveland Guardians vs Minnesota Twins - Sun, Sep 21, 2025 | Away | Target Field |
| Tue, Sep 23, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Tue, Sep 23, 2025 | Home | Progressive Field |
| Wed, Sep 24, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Wed, Sep 24, 2025 | Home | Progressive Field |
| Thu, Sep 25, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Thu, Sep 25, 2025 | Home | Progressive Field |
| Fri, Sep 26, 2025 | Texas Rangers | Cleveland Guardians vs Texas Rangers - Fri, Sep 26, 2025 | Home | Progressive Field |
| Sat, Sep 27, 2025 | Texas Rangers | Cleveland Guardians vs Texas Rangers - Sat, Sep 27, 2025 | Home | Progressive Field |
| Sun, Sep 28, 2025 | Texas Rangers | Cleveland Guardians vs Texas Rangers - Sun, Sep 28, 2025 | Home | Progressive Field |
| Tue, Sep 30, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Tue, Sep 30, 2025 | Home | Progressive Field |
| Wed, Oct 1, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Wed, Oct 1, 2025 | Home | Progressive Field |
| Thu, Oct 2, 2025 | Detroit Tigers | Cleveland Guardians vs Detroit Tigers - Thu, Oct 2, 2025 | Home | Progressive Field |
